PMID- 23040474
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20220316
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 11
IP  - 4
DP  - 2012 Oct 5
TI  - Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
PG  - 452-60
LID - S1934-5909(12)00546-2 [pii]
LID - 10.1016/j.stem.2012.09.009 [doi]
AB  - Decades ago, two nonoverlapping crypt stem cell populations were proposed: 
      Leblond's Crypt Base Columnar (CBC) cell and Potten's +4 cell. The identification 
      of CBC markers including Lgr5 has confirmed Leblond's predictions that CBC cells 
      are anatomically distinct, long-lived stem cells that permanently cycle. While 
      Potten originally described +4 cells as proliferative and unusually 
      radiation-sensitive, recent efforts to identify +4 stem cells have focused on the 
      identification of cells that are quiescent and radiation-resistant. Here, we 
      describe commonalities and discrepancies between the individual studies and 
      discuss challenges of marker-based lineage tracing.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Barker, Nick
AU  - Barker N
AD  - Institute of Medical Biology, 8A Biomedical Grove, Immunos 138648, Singapore.
FAU - van Oudenaarden, Alexander
AU  - van Oudenaarden A
FAU - Clevers, Hans
AU  - Clevers H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
RN  - 0 (Biomarkers)
RN  - 0 (LGR5 protein, human)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Adult Stem Cells/*cytology/*physiology
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Cycle
MH  - Cell Movement
MH  - Cell Separation
MH  - Cell Surface Extensions/*metabolism
MH  - Humans
MH  - Intestines/*cytology
MH  - Radiation Tolerance
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Wnt Signaling Pathway
EDAT- 2012/10/09 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - S1934-5909(12)00546-2 [pii]
AID - 10.1016/j.stem.2012.09.009 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2012 Oct 5;11(4):452-60. doi: 10.1016/j.stem.2012.09.009.