PMID- 23128233
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20220510
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 491
IP  - 7422
DP  - 2012 Nov 1
TI  - Host-microbe interactions have shaped the genetic architecture of inflammatory 
      bowel disease.
PG  - 119-24
LID - 10.1038/nature11582 [doi]
AB  - Crohn's disease and ulcerative colitis, the two common forms of inflammatory 
      bowel disease (IBD), affect over 2.5 million people of European ancestry, with 
      rising prevalence in other populations. Genome-wide association studies and 
      subsequent meta-analyses of these two diseases as separate phenotypes have 
      implicated previously unsuspected mechanisms, such as autophagy, in their 
      pathogenesis and showed that some IBD loci are shared with other inflammatory 
      diseases. Here we expand on the knowledge of relevant pathways by undertaking a 
      meta-analysis of Crohn's disease and ulcerative colitis genome-wide association 
      scans, followed by extensive validation of significant findings, with a combined 
      total of more than 75,000 cases and controls. We identify 71 new associations, 
      for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most 
      loci contribute to both phenotypes, and both directional (consistently favouring 
      one allele over the course of human history) and balancing (favouring the 
      retention of both alleles within populations) selection effects are evident. Many 
      IBD loci are also implicated in other immune-mediated disorders, most notably 
      with ankylosing spondylitis and psoriasis. We also observe considerable overlap 
      between susceptibility loci for IBD and mycobacterial infection. Gene 
      co-expression network analysis emphasizes this relationship, with pathways shared 
      between host responses to mycobacteria and those predisposing to IBD.
FAU - Jostins, Luke
AU  - Jostins L
AD  - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge 
      CB10 1HH, UK.
FAU - Ripke, Stephan
AU  - Ripke S
FAU - Weersma, Rinse K
AU  - Weersma RK
FAU - Duerr, Richard H
AU  - Duerr RH
FAU - McGovern, Dermot P
AU  - McGovern DP
FAU - Hui, Ken Y
AU  - Hui KY
FAU - Lee, James C
AU  - Lee JC
FAU - Schumm, L Philip
AU  - Schumm LP
FAU - Sharma, Yashoda
AU  - Sharma Y
FAU - Anderson, Carl A
AU  - Anderson CA
FAU - Essers, Jonah
AU  - Essers J
FAU - Mitrovic, Mitja
AU  - Mitrovic M
FAU - Ning, Kaida
AU  - Ning K
FAU - Cleynen, Isabelle
AU  - Cleynen I
FAU - Theatre, Emilie
AU  - Theatre E
FAU - Spain, Sarah L
AU  - Spain SL
FAU - Raychaudhuri, Soumya
AU  - Raychaudhuri S
FAU - Goyette, Philippe
AU  - Goyette P
FAU - Wei, Zhi
AU  - Wei Z
FAU - Abraham, Clara
AU  - Abraham C
FAU - Achkar, Jean-Paul
AU  - Achkar JP
FAU - Ahmad, Tariq
AU  - Ahmad T
FAU - Amininejad, Leila
AU  - Amininejad L
FAU - Ananthakrishnan, Ashwin N
AU  - Ananthakrishnan AN
FAU - Andersen, Vibeke
AU  - Andersen V
FAU - Andrews, Jane M
AU  - Andrews JM
FAU - Baidoo, Leonard
AU  - Baidoo L
FAU - Balschun, Tobias
AU  - Balschun T
FAU - Bampton, Peter A
AU  - Bampton PA
FAU - Bitton, Alain
AU  - Bitton A
FAU - Boucher, Gabrielle
AU  - Boucher G
FAU - Brand, Stephan
AU  - Brand S
FAU - Buning, Carsten
AU  - Buning C
FAU - Cohain, Ariella
AU  - Cohain A
FAU - Cichon, Sven
AU  - Cichon S
FAU - D'Amato, Mauro
AU  - D'Amato M
FAU - De Jong, Dirk
AU  - De Jong D
FAU - Devaney, Kathy L
AU  - Devaney KL
FAU - Dubinsky, Marla
AU  - Dubinsky M
FAU - Edwards, Cathryn
AU  - Edwards C
FAU - Ellinghaus, David
AU  - Ellinghaus D
FAU - Ferguson, Lynnette R
AU  - Ferguson LR
FAU - Franchimont, Denis
AU  - Franchimont D
FAU - Fransen, Karin
AU  - Fransen K
FAU - Gearry, Richard
AU  - Gearry R
FAU - Georges, Michel
AU  - Georges M
FAU - Gieger, Christian
AU  - Gieger C
FAU - Glas, Jurgen
AU  - Glas J
FAU - Haritunians, Talin
AU  - Haritunians T
FAU - Hart, Ailsa
AU  - Hart A
FAU - Hawkey, Chris
AU  - Hawkey C
FAU - Hedl, Matija
AU  - Hedl M
FAU - Hu, Xinli
AU  - Hu X
FAU - Karlsen, Tom H
AU  - Karlsen TH
FAU - Kupcinskas, Limas
AU  - Kupcinskas L
FAU - Kugathasan, Subra
AU  - Kugathasan S
FAU - Latiano, Anna
AU  - Latiano A
FAU - Laukens, Debby
AU  - Laukens D
FAU - Lawrance, Ian C
AU  - Lawrance IC
FAU - Lees, Charlie W
AU  - Lees CW
FAU - Louis, Edouard
AU  - Louis E
FAU - Mahy, Gillian
AU  - Mahy G
FAU - Mansfield, John
AU  - Mansfield J
FAU - Morgan, Angharad R
AU  - Morgan AR
FAU - Mowat, Craig
AU  - Mowat C
FAU - Newman, William
AU  - Newman W
FAU - Palmieri, Orazio
AU  - Palmieri O
FAU - Ponsioen, Cyriel Y
AU  - Ponsioen CY
FAU - Potocnik, Uros
AU  - Potocnik U
FAU - Prescott, Natalie J
AU  - Prescott NJ
FAU - Regueiro, Miguel
AU  - Regueiro M
FAU - Rotter, Jerome I
AU  - Rotter JI
FAU - Russell, Richard K
AU  - Russell RK
FAU - Sanderson, Jeremy D
AU  - Sanderson JD
FAU - Sans, Miquel
AU  - Sans M
FAU - Satsangi, Jack
AU  - Satsangi J
FAU - Schreiber, Stefan
AU  - Schreiber S
FAU - Simms, Lisa A
AU  - Simms LA
FAU - Sventoraityte, Jurgita
AU  - Sventoraityte J
FAU - Targan, Stephan R
AU  - Targan SR
FAU - Taylor, Kent D
AU  - Taylor KD
FAU - Tremelling, Mark
AU  - Tremelling M
FAU - Verspaget, Hein W
AU  - Verspaget HW
FAU - De Vos, Martine
AU  - De Vos M
FAU - Wijmenga, Cisca
AU  - Wijmenga C
FAU - Wilson, David C
AU  - Wilson DC
FAU - Winkelmann, Juliane
AU  - Winkelmann J
FAU - Xavier, Ramnik J
AU  - Xavier RJ
FAU - Zeissig, Sebastian
AU  - Zeissig S
FAU - Zhang, Bin
AU  - Zhang B
FAU - Zhang, Clarence K
AU  - Zhang CK
FAU - Zhao, Hongyu
AU  - Zhao H
CN  - International IBD Genetics Consortium (IIBDGC)
FAU - Silverberg, Mark S
AU  - Silverberg MS
FAU - Annese, Vito
AU  - Annese V
FAU - Hakonarson, Hakon
AU  - Hakonarson H
FAU - Brant, Steven R
AU  - Brant SR
FAU - Radford-Smith, Graham
AU  - Radford-Smith G
FAU - Mathew, Christopher G
AU  - Mathew CG
FAU - Rioux, John D
AU  - Rioux JD
FAU - Schadt, Eric E
AU  - Schadt EE
FAU - Daly, Mark J
AU  - Daly MJ
FAU - Franke, Andre
AU  - Franke A
FAU - Parkes, Miles
AU  - Parkes M
FAU - Vermeire, Severine
AU  - Vermeire S
FAU - Barrett, Jeffrey C
AU  - Barrett JC
FAU - Cho, Judy H
AU  - Cho JH
LA  - eng
GR  - DK043351/DK/NIDDK NIH HHS/United States
GR  - G0800759/MRC_/Medical Research Council/United Kingdom
GR  - DK062423/DK/NIDDK NIH HHS/United States
GR  - U01 DK062432/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000124/TR/NCATS NIH HHS/United States
GR  - ETM/137/CSO_/Chief Scientist Office/United Kingdom
GR  - U01 DK062422/DK/NIDDK NIH HHS/United States
GR  - DK83756/DK/NIDDK NIH HHS/United States
GR  - DK062431/DK/NIDDK NIH HHS/United States
GR  - M01 RR000425/RR/NCRR NIH HHS/United States
GR  - DK062429/DK/NIDDK NIH HHS/United States
GR  - 098051/WT_/Wellcome Trust/United Kingdom
GR  - M01-RR00425/RR/NCRR NIH HHS/United States
GR  - AI062773/AI/NIAID NIH HHS/United States
GR  - T32GM07205/GM/NIGMS NIH HHS/United States
GR  - R01 CA141743/CA/NCI NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - G1002033/MRC_/Medical Research Council/United Kingdom
GR  - DK062422/DK/NIDDK NIH HHS/United States
GR  - U01 DK062413/DK/NIDDK NIH HHS/United States
GR  - DK062429-S1/DK/NIDDK NIH HHS/United States
GR  - R01 DK055731/DK/NIDDK NIH HHS/United States
GR  - G0800675/MRC_/Medical Research Council/United Kingdom
GR  - 083948/Z/07/Z/WT_/Wellcome Trust/United Kingdom
GR  - P30 DK043351/DK/NIDDK NIH HHS/United States
GR  - G0600329/MRC_/Medical Research Council/United Kingdom
GR  - R21 DK084554/DK/NIDDK NIH HHS/United States
GR  - 068545/Z/02/WT_/Wellcome Trust/United Kingdom
GR  - 18475/ARC_/Arthritis Research UK/United Kingdom
GR  - 085475/B/08/Z/WT_/Wellcome Trust/United Kingdom
GR  - P01DK046763/DK/NIDDK NIH HHS/United States
GR  - U01 DK062429/DK/NIDDK NIH HHS/United States
GR  - ETM/75/CSO_/Chief Scientist Office/United Kingdom
GR  - K23 DK097142/DK/NIDDK NIH HHS/United States
GR  - U01 DK062418/DK/NIDDK NIH HHS/United States
GR  - P30 DK063491/DK/NIDDK NIH HHS/United States
GR  - CZB/4/540/CSO_/Chief Scientist Office/United Kingdom
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - T32 GM007205/GM/NIGMS NIH HHS/United States
GR  - R01 AI062773/AI/NIAID NIH HHS/United States
GR  - DK062420/DK/NIDDK NIH HHS/United States
GR  - R03 DK076984/DK/NIDDK NIH HHS/United States
GR  - DK076984/DK/NIDDK NIH HHS/United States
GR  - 089120/WT_/Wellcome Trust/United Kingdom
GR  - DK063491/DK/NIDDK NIH HHS/United States
GR  - G0000934/BHF_/British Heart Foundation/United Kingdom
GR  - U01 DK062423/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000124-01/TR/NCATS NIH HHS/United States
GR  - P01 DK046763/DK/NIDDK NIH HHS/United States
GR  - R01 DK083756/DK/NIDDK NIH HHS/United States
GR  - DK062432/DK/NIDDK NIH HHS/United States
GR  - 085475/Z/08/Z/WT_/Wellcome Trust/United Kingdom
GR  - DK062413/DK/NIDDK NIH HHS/United States
GR  - U01 DK062420/DK/NIDDK NIH HHS/United States
GR  - U01 DK062431/DK/NIDDK NIH HHS/United States
GR  - 18475/VAC_/Versus Arthritis/United Kingdom
GR  - DK084554/DK/NIDDK NIH HHS/United States
GR  - CA141743/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CIN - Nat Rev Gastroenterol Hepatol. 2012 Dec;9(12):685. PMID: 23147660
MH  - Colitis, Ulcerative/genetics/immunology/microbiology/physiopathology
MH  - Crohn Disease/genetics/immunology/microbiology/physiopathology
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome, Human/genetics
MH  - *Genome-Wide Association Study
MH  - Haplotypes/genetics
MH  - *Host-Pathogen Interactions/genetics/immunology
MH  - Humans
MH  - Inflammatory Bowel Diseases/*genetics/immunology/*microbiology/physiopathology
MH  - Mycobacterium/*immunology/pathogenicity
MH  - Mycobacterium Infections/genetics/microbiology
MH  - Mycobacterium tuberculosis/immunology/pathogenicity
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Reproducibility of Results
PMC - PMC3491803
MID - NIHMS407586
FIR - Barclay, Murray
IR  - Barclay M
FIR - Peyrin-Biroulet, Laurent
IR  - Peyrin-Biroulet L
FIR - Chamaillard, Mathias
IR  - Chamaillard M
FIR - Colombel, Jean-Frederick
IR  - Colombel JF
FIR - Cottone, Mario
IR  - Cottone M
FIR - Croft, Anthony
IR  - Croft A
FIR - D'Inca, Renata
IR  - D'Inca R
FIR - Halfvarson, Jonas
IR  - Halfvarson J
FIR - Hanigan, Katherine
IR  - Hanigan K
FIR - Henderson, Paul
IR  - Henderson P
FIR - Hugot, Jean-Pierre
IR  - Hugot JP
FIR - Karban, Amir
IR  - Karban A
FIR - Kennedy, Nicholas A
IR  - Kennedy NA
FIR - Khan, Mohammed Azam
IR  - Khan MA
FIR - Lemann, Marc
IR  - Lemann M
FIR - Levine, Arie
IR  - Levine A
FIR - Massey, Dunecan
IR  - Massey D
FIR - Milla, Monica
IR  - Milla M
FIR - Montgomery, Grant W
IR  - Montgomery GW
FIR - Ng, Sok Meng Evelyn
IR  - Ng SM
FIR - Oikonomou, Ioannis
IR  - Oikonomou I
FIR - Peeters, Harald
IR  - Peeters H
FIR - Proctor, Deborah D
IR  - Proctor DD
FIR - Rahier, Jean-Francois
IR  - Rahier JF
FIR - Roberts, Rebecca
IR  - Roberts R
FIR - Rutgeerts, Paul
IR  - Rutgeerts P
FIR - Seibold, Frank
IR  - Seibold F
FIR - Stronati, Laura
IR  - Stronati L
FIR - Taylor, Kirstin M
IR  - Taylor KM
FIR - Torkvist, Leif
IR  - Torkvist L
FIR - Ublick, Kullak
IR  - Ublick K
FIR - Van Limbergen, Johan
IR  - Van Limbergen J
FIR - Van Gossum, Andre
IR  - Van Gossum A
FIR - Vatn, Morten H
IR  - Vatn MH
FIR - Zhang, Hu
IR  - Zhang H
FIR - Zhang, Wei
IR  - Zhang W
FIR - Andrews, Jane M
IR  - Andrews JM
FIR - Bampton, Peter A
IR  - Bampton PA
FIR - Barclay, Murray
IR  - Barclay M
FIR - Florin, Timothy H
IR  - Florin TH
FIR - Gearry, Richard
IR  - Gearry R
FIR - Krishnaprasad, Krupa
IR  - Krishnaprasad K
FIR - Lawrance, Ian C
IR  - Lawrance IC
FIR - Mahy, Gillian
IR  - Mahy G
FIR - Montgomery, Grant W
IR  - Montgomery GW
FIR - Radford-Smith, Graham
IR  - Radford-Smith G
FIR - Roberts, Rebecca L
IR  - Roberts RL
FIR - Simms, Lisa A
IR  - Simms LA
FIR - Amininijad, Leila
IR  - Amininijad L
FIR - Cleynen, Isabelle
IR  - Cleynen I
FIR - Dewit, Olivier
IR  - Dewit O
FIR - Franchimont, Denis
IR  - Franchimont D
FIR - Georges, Michel
IR  - Georges M
FIR - Laukens, Debby
IR  - Laukens D
FIR - Peeters, Harald
IR  - Peeters H
FIR - Rahier, Jean-Francois
IR  - Rahier JF
FIR - Rutgeerts, Paul
IR  - Rutgeerts P
FIR - Theatre, Emilie
IR  - Theatre E
FIR - Van Gossum, Andre
IR  - Van Gossum A
FIR - Vermeire, Severine
IR  - Vermeire S
FIR - Aumais, Guy
IR  - Aumais G
FIR - Baidoo, Leonard
IR  - Baidoo L
FIR - Barrie, Arthur M 3rd
IR  - Barrie AM 3rd
FIR - Beck, Karen
IR  - Beck K
FIR - Bernard, Edmond-Jean
IR  - Bernard EJ
FIR - Binion, David G
IR  - Binion DG
FIR - Bitton, Alain
IR  - Bitton A
FIR - Brant, Steve R
IR  - Brant SR
FIR - Cho, Judy H
IR  - Cho JH
FIR - Cohen, Albert
IR  - Cohen A
FIR - Croitoru, Kenneth
IR  - Croitoru K
FIR - Daly, Mark J
IR  - Daly MJ
FIR - Datta, Lisa W
IR  - Datta LW
FIR - Deslandres, Colette
IR  - Deslandres C
FIR - Duerr, Richard H
IR  - Duerr RH
FIR - Dutridge, Debra
IR  - Dutridge D
FIR - Ferguson, John
IR  - Ferguson J
FIR - Fultz, Joann
IR  - Fultz J
FIR - Goyette, Philippe
IR  - Goyette P
FIR - Greenberg, Gordon R
IR  - Greenberg GR
FIR - Haritunians, Talin
IR  - Haritunians T
FIR - Jobin, Gilles
IR  - Jobin G
FIR - Katz, Seymour
IR  - Katz S
FIR - Lahaie, Raymond G
IR  - Lahaie RG
FIR - McGovern, Dermot P
IR  - McGovern DP
FIR - Nelson, Linda
IR  - Nelson L
FIR - Ng, Sok Meng
IR  - Ng SM
FIR - Ning, Kaida
IR  - Ning K
FIR - Oikonomou, Ioannis
IR  - Oikonomou I
FIR - Pare, Pierre
IR  - Pare P
FIR - Proctor, Deborah D
IR  - Proctor DD
FIR - Regueiro, Miguel D
IR  - Regueiro MD
FIR - Rioux, John D
IR  - Rioux JD
FIR - Ruggiero, Elizabeth
IR  - Ruggiero E
FIR - Schumm, L Philip
IR  - Schumm L
FIR - Schwartz, Marc
IR  - Schwartz M
FIR - Scott, Regan
IR  - Scott R
FIR - Sharma, Yashoda
IR  - Sharma Y
FIR - Silverberg, Mark S
IR  - Silverberg MS
FIR - Spears, Denise
IR  - Spears D
FIR - Steinhart, A Hillary
IR  - Steinhart A
FIR - Stempak, Joanne M
IR  - Stempak JM
FIR - Swoger, Jason M
IR  - Swoger JM
FIR - Tsagarelis, Constantina
IR  - Tsagarelis C
FIR - Zhang, Wei
IR  - Zhang W
FIR - Zhang, Clarence
IR  - Zhang C
FIR - Zhao, Hongyu
IR  - Zhao H
FIR - Aerts, Jan
IR  - Aerts J
FIR - Ahmad, Tariq
IR  - Ahmad T
FIR - Arbury, Hazel
IR  - Arbury H
FIR - Attwood, Anthony
IR  - Attwood A
FIR - Auton, Adam
IR  - Auton A
FIR - Ball, Stephen G
IR  - Ball SG
FIR - Balmforth, Anthony J
IR  - Balmforth AJ
FIR - Barnes, Chris
IR  - Barnes C
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IR  - Barrett JC
FIR - Barroso, Ines
IR  - Barroso I
FIR - Barton, Anne
IR  - Barton A
FIR - Bennett, Amanda J
IR  - Bennett AJ
FIR - Bhaskar, Sanjeev
IR  - Bhaskar S
FIR - Blaszczyk, Katarzyna
IR  - Blaszczyk K
FIR - Bowes, John
IR  - Bowes J
FIR - Brand, Oliver J
IR  - Brand OJ
FIR - Braund, Peter S
IR  - Braund PS
FIR - Bredin, Francesca
IR  - Bredin F
FIR - Breen, Gerome
IR  - Breen G
FIR - Brown, Morris J
IR  - Brown MJ
FIR - Bruce, Ian N
IR  - Bruce IN
FIR - Bull, Jaswinder
IR  - Bull J
FIR - Burren, Oliver S
IR  - Burren OS
FIR - Burton, John
IR  - Burton J
FIR - Byrnes, Jake
IR  - Byrnes J
FIR - Caesar, Sian
IR  - Caesar S
FIR - Cardin, Niall
IR  - Cardin N
FIR - Clee, Chris M
IR  - Clee CM
FIR - Coffey, Alison J
IR  - Coffey AJ
FIR - Connell, John M C
IR  - Connell JM
FIR - Conrad, Donald F
IR  - Conrad DF
FIR - Cooper, Jason D
IR  - Cooper JD
FIR - Dominiczak, Anna F
IR  - Dominiczak AF
FIR - Downes, Kate
IR  - Downes K
FIR - Drummond, Hazel E
IR  - Drummond HE
FIR - Dudakia, Darshna
IR  - Dudakia D
FIR - Dunham, Andrew
IR  - Dunham A
FIR - Ebbs, Bernadette
IR  - Ebbs B
FIR - Eccles, Diana
IR  - Eccles D
FIR - Edkins, Sarah
IR  - Edkins S
FIR - Edwards, Cathryn
IR  - Edwards C
FIR - Elliot, Anna
IR  - Elliot A
FIR - Emery, Paul
IR  - Emery P
FIR - Evans, David M
IR  - Evans DM
FIR - Evans, Gareth
IR  - Evans G
FIR - Eyre, Steve
IR  - Eyre S
FIR - Farmer, Anne
IR  - Farmer A
FIR - Ferrier, I Nicol
IR  - Ferrier IN
FIR - Flynn, Edward
IR  - Flynn E
FIR - Forbes, Alistair
IR  - Forbes A
FIR - Forty, Liz
IR  - Forty L
FIR - Franklyn, Jayne A
IR  - Franklyn JA
FIR - Frayling, Timothy M
IR  - Frayling TM
FIR - Freathy, Rachel M
IR  - Freathy RM
FIR - Giannoulatou, Eleni
IR  - Giannoulatou E
FIR - Gibbs, Polly
IR  - Gibbs P
FIR - Gilbert, Paul
IR  - Gilbert P
FIR - Gordon-Smith, Katherine
IR  - Gordon-Smith K
FIR - Gray, Emma
IR  - Gray E
FIR - Green, Elaine
IR  - Green E
FIR - Groves, Chris J
IR  - Groves CJ
FIR - Grozeva, Detelina
IR  - Grozeva D
FIR - Gwilliam, Rhian
IR  - Gwilliam R
FIR - Hall, Anita
IR  - Hall A
FIR - Hammond, Naomi
IR  - Hammond N
FIR - Hardy, Matt
IR  - Hardy M
FIR - Harrison, Pile
IR  - Harrison P
FIR - Hassanali, Neelam
IR  - Hassanali N
FIR - Hebaishi, Husam
IR  - Hebaishi H
FIR - Hines, Sarah
IR  - Hines S
FIR - Hinks, Anne
IR  - Hinks A
FIR - Hitman, Graham A
IR  - Hitman GA
FIR - Hocking, Lynne
IR  - Hocking L
FIR - Holmes, Chris
IR  - Holmes C
FIR - Howard, Eleanor
IR  - Howard E
FIR - Howard, Philip
IR  - Howard P
FIR - Howson, Joanna M M
IR  - Howson JM
FIR - Hughes, Debbie
IR  - Hughes D
FIR - Hunt, Sarah
IR  - Hunt S
FIR - Isaacs, John D
IR  - Isaacs JD
FIR - Jain, Mahim
IR  - Jain M
FIR - Jewell, Derek P
IR  - Jewell DP
FIR - Johnson, Toby
IR  - Johnson T
FIR - Jolley, Jennifer D
IR  - Jolley JD
FIR - Jones, Ian R
IR  - Jones IR
FIR - Jones, Lisa A
IR  - Jones LA
FIR - Kirov, George
IR  - Kirov G
FIR - Langford, Cordelia F
IR  - Langford CF
FIR - Lango-Allen, Hana
IR  - Lango-Allen H
FIR - Lathrop, G Mark
IR  - Lathrop GM
FIR - Lee, James
IR  - Lee J
FIR - Lee, Kate L
IR  - Lee KL
FIR - Lees, Charlie
IR  - Lees C
FIR - Lewis, Kevin
IR  - Lewis K
FIR - Lindgren, Cecilia M
IR  - Lindgren CM
FIR - Maisuria-Armer, Meeta
IR  - Maisuria-Armer M
FIR - Maller, Julian
IR  - Maller J
FIR - Mansfield, John
IR  - Mansfield J
FIR - Marchini, Jonathan L
IR  - Marchini JL
FIR - Martin, Paul
IR  - Martin P
FIR - Massey, Dunecan C O
IR  - Massey DC
FIR - McArdle, Wendy L
IR  - McArdle WL
FIR - McGuffin, Peter
IR  - McGuffin P
FIR - McLay, Kirsten E
IR  - McLay KE
FIR - McVean, Gil
IR  - McVean G
FIR - Mentzer, Alex
IR  - Mentzer A
FIR - Mimmack, Michael L
IR  - Mimmack ML
FIR - Morgan, Ann E
IR  - Morgan AE
FIR - Morris, Andrew P
IR  - Morris AP
FIR - Mowat, Craig
IR  - Mowat C
FIR - Munroe, Patricia B
IR  - Munroe PB
FIR - Myers, Simon
IR  - Myers S
FIR - Newman, William
IR  - Newman W
FIR - Nimmo, Elaine R
IR  - Nimmo ER
FIR - O'Donovan, Michael C
IR  - O'Donovan MC
FIR - Onipinla, Abiodun
IR  - Onipinla A
FIR - Ovington, Nigel R
IR  - Ovington NR
FIR - Owen, Michael J
IR  - Owen MJ
FIR - Palin, Kimmo
IR  - Palin K
FIR - Palotie, Aarno
IR  - Palotie A
FIR - Parnell, Kirstie
IR  - Parnell K
FIR - Pearson, Richard
IR  - Pearson R
FIR - Pernet, David
IR  - Pernet D
FIR - Perry, John R B
IR  - Perry JR
FIR - Phillips, Anne
IR  - Phillips A
FIR - Plagnol, Vincent
IR  - Plagnol V
FIR - Prescott, Natalie J
IR  - Prescott NJ
FIR - Prokopenko, Inga
IR  - Prokopenko I
FIR - Quail, Michael A
IR  - Quail MA
FIR - Rafelt, Suzanne
IR  - Rafelt S
FIR - Rayner, Nigel W
IR  - Rayner NW
FIR - Reid, David M
IR  - Reid DM
FIR - Renwick, Anthony
IR  - Renwick A
FIR - Ring, Susan M
IR  - Ring SM
FIR - Robertson, Neil
IR  - Robertson N
FIR - Robson, Samuel
IR  - Robson S
FIR - Russell, Ellie
IR  - Russell E
FIR - St Clair, David
IR  - St Clair D
FIR - Sambrook, Jennifer G
IR  - Sambrook JG
FIR - Sanderson, Jeremy D
IR  - Sanderson JD
FIR - Sawcer, Stephen J
IR  - Sawcer SJ
FIR - Schuilenburg, Helen
IR  - Schuilenburg H
FIR - Scott, Carol E
IR  - Scott CE
FIR - Scott, Richard
IR  - Scott R
FIR - Seal, Sheila
IR  - Seal S
FIR - Shaw-Hawkins, Sue
IR  - Shaw-Hawkins S
FIR - Shields, Beverley M
IR  - Shields BM
FIR - Simmonds, Matthew J
IR  - Simmonds MJ
FIR - Smyth, Debbie J
IR  - Smyth DJ
FIR - Somaskantharajah, Elilan
IR  - Somaskantharajah E
FIR - Spanova, Katarina
IR  - Spanova K
FIR - Steer, Sophia
IR  - Steer S
FIR - Stephens, Jonathan
IR  - Stephens J
FIR - Stevens, Helen E
IR  - Stevens HE
FIR - Stirrups, Kathy
IR  - Stirrups K
FIR - Stone, Millicent A
IR  - Stone MA
FIR - Strachan, David P
IR  - Strachan DP
FIR - Su, Zhan
IR  - Su Z
FIR - Symmons, Deborah P M
IR  - Symmons DP
FIR - Thompson, John R
IR  - Thompson JR
FIR - Thomson, Wendy
IR  - Thomson W
FIR - Tobin, Martin D
IR  - Tobin MD
FIR - Travers, Mary E
IR  - Travers ME
FIR - Turnbull, Clare
IR  - Turnbull C
FIR - Vukcevic, Damjan
IR  - Vukcevic D
FIR - Wain, Louise V
IR  - Wain LV
FIR - Walker, Mark
IR  - Walker M
FIR - Walker, Neil M
IR  - Walker NM
FIR - Wallace, Chris
IR  - Wallace C
FIR - Warren-Perry, Margaret
IR  - Warren-Perry M
FIR - Watkins, Nicholas A
IR  - Watkins NA
FIR - Webster, John
IR  - Webster J
FIR - Weedon, Michael N
IR  - Weedon MN
FIR - Wilson, Anthony G
IR  - Wilson AG
FIR - Woodburn, Matthew
IR  - Woodburn M
FIR - Wordsworth, B Paul
IR  - Wordsworth BP
FIR - Yau, Chris
IR  - Yau C
FIR - Young, Allan H
IR  - Young AH
FIR - Zeggini, Eleftheria
IR  - Zeggini E
FIR - Brown, Matthew A
IR  - Brown MA
FIR - Burton, Paul R
IR  - Burton PR
FIR - Caulfield, Mark J
IR  - Caulfield MJ
FIR - Compston, Alastair
IR  - Compston A
FIR - Farrall, Martin
IR  - Farrall M
FIR - Gough, Stephen C L
IR  - Gough SC
FIR - Hall, Alistair S
IR  - Hall AS
FIR - Hattersley, Andrew T
IR  - Hattersley AT
FIR - Hill, Adrian V S
IR  - Hill AV
FIR - Mathew, Christopher G
IR  - Mathew CG
FIR - Pembrey, Marcus
IR  - Pembrey M
FIR - Satsangi, Jack
IR  - Satsangi J
FIR - Stratton, Michael R
IR  - Stratton MR
FIR - Worthington, Jane
IR  - Worthington J
FIR - Hurles, Matthew E
IR  - Hurles ME
FIR - Duncanson, Audrey
IR  - Duncanson A
FIR - Ouwehand, Willem H
IR  - Ouwehand WH
FIR - Parkes, Miles
IR  - Parkes M
FIR - Rahman, Nazneen
IR  - Rahman N
FIR - Todd, John A
IR  - Todd JA
FIR - Samani, Nilesh J
IR  - Samani NJ
FIR - Kwiatkowski, Dominic P
IR  - Kwiatkowski DP
FIR - McCarthy, Mark I
IR  - McCarthy MI
FIR - Craddock, Nick
IR  - Craddock N
FIR - Deloukas, Panos
IR  - Deloukas P
FIR - Donnelly, Peter
IR  - Donnelly P
FIR - Blackwell, Jenefer M
IR  - Blackwell JM
FIR - Bramon, Elvira
IR  - Bramon E
FIR - Casas, Juan P
IR  - Casas JP
FIR - Corvin, Aiden
IR  - Corvin A
FIR - Jankowski, Janusz
IR  - Jankowski J
FIR - Markus, Hugh S
IR  - Markus HS
FIR - Palmer, Colin N A
IR  - Palmer CN
FIR - Plomin, Robert
IR  - Plomin R
FIR - Rautanen, Anna
IR  - Rautanen A
FIR - Trembath, Richard C
IR  - Trembath RC
FIR - Viswanathan, Ananth C
IR  - Viswanathan AC
FIR - Wood, Nicholas W
IR  - Wood NW
FIR - Spencer, Chris C A
IR  - Spencer CC
FIR - Band, Gavin
IR  - Band G
FIR - Bellenguez, Celine
IR  - Bellenguez C
FIR - Freeman, Colin
IR  - Freeman C
FIR - Hellenthal, Garrett
IR  - Hellenthal G
FIR - Giannoulatou, Eleni
IR  - Giannoulatou E
FIR - Pirinen, Matti
IR  - Pirinen M
FIR - Pearson, Richard
IR  - Pearson R
FIR - Strange, Amy
IR  - Strange A
FIR - Blackburn, Hannah
IR  - Blackburn H
FIR - Bumpstead, Suzannah J
IR  - Bumpstead SJ
FIR - Dronov, Serge
IR  - Dronov S
FIR - Gillman, Matthew
IR  - Gillman M
FIR - Jayakumar, Alagurevathi
IR  - Jayakumar A
FIR - McCann, Owen T
IR  - McCann OT
FIR - Liddle, Jennifer
IR  - Liddle J
FIR - Potter, Simon C
IR  - Potter SC
FIR - Ravindrarajah, Radhi
IR  - Ravindrarajah R
FIR - Ricketts, Michelle
IR  - Ricketts M
FIR - Waller, Matthew
IR  - Waller M
FIR - Weston, Paul
IR  - Weston P
FIR - Widaa, Sara
IR  - Widaa S
FIR - Whittaker, Pamela
IR  - Whittaker P
EDAT- 2012/11/07 06:00
MHDA- 2012/12/27 06:00
PMCR- 2013/05/01
CRDT- 2012/11/07 06:00
PHST- 2012/05/17 00:00 [received]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - nature11582 [pii]
AID - 10.1038/nature11582 [doi]
PST - ppublish
SO  - Nature. 2012 Nov 1;491(7422):119-24. doi: 10.1038/nature11582.