PMID- 23152036
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20211021
IS  - 1432-086X (Electronic)
IS  - 0174-1551 (Print)
IS  - 0174-1551 (Linking)
VI  - 36
IP  - 4
DP  - 2013 Aug
TI  - Pattern of retained contrast on immediate postprocedure computed tomography (CT) 
      after particle embolization of liver tumors predicts subsequent treatment 
      response.
PG  - 1030-8
LID - 10.1007/s00270-012-0506-x [doi]
AB  - PURPOSE: To determine if the pattern of retained contrast on immediate 
      postprocedure computed tomography (CT) after particle embolization of hepatic 
      tumors predicts modified Response Evaluation Criteria in Solid Tumors (mRECIST) 
      response. MATERIALS AND METHODS: This study was approved by the Institutional 
      Review Board with a waiver of authorization. One hundred four liver tumors were 
      embolized with spherical embolic agents (Embospheres, Bead Block, LC Bead) and 
      polyvinyl alcohol. Noncontrast CT was performed immediately after embolization to 
      assess contrast retention in the targeted tumors, and treatment response was 
      assessed by mRECIST criteria on follow-up CT (average time 9.0 +/- 7.7 weeks after 
      embolization). Tumor contrast retention (TCR) was determined based on change in 
      Hounsfield units (HUs) of the index tumors between the preprocedure and immediate 
      postprocedure scans; vascular contrast retention (VCR) was rated; and defects in 
      contrast retention (DCR) were also documented. The morphology of residual 
      enhancing tumor on follow-up CT was described as partial, circumferential, or 
      total. Association between TCR variables and tumor response were assessed using 
      multivariate logistic regression. RESULTS: Of 104 hepatic tumors, 51 (49%) tumors 
      had complete response (CR) by mRECIST criteria; 23 (22.1%) had partial response 
      (PR); 21 (20.2%) had stable disease (SD); and 9 (8.7%) had progressive disease 
      (PD). By multivariate analysis, TCR, VCR, and tumor size are independent 
      predictors of CR (p = 0.02, 0.05, and 0.005 respectively). In 75 tumors, DCR was 
      found to be an independent predictor of failure to achieve complete response (p < 
      0.0001) by imaging criteria. CONCLUSION: TCR, VCR, and DCR on immediate 
      posttreatment CT are independent predictors of CR by mRECIST criteria.
FAU - Wang, Xiaodong
AU  - Wang X
AD  - Interventional Radiology Service, Department of Radiology, Memorial 
      Sloan-Kettering Cancer Center, 1275 York Ave, Room H118, New York, NY 10065, USA. 
      wangxde@gmail.com
FAU - Erinjeri, Joseph P
AU  - Erinjeri JP
FAU - Jia, Xiaoyu
AU  - Jia X
FAU - Gonen, Mithat
AU  - Gonen M
FAU - Brown, Karen T
AU  - Brown KT
FAU - Sofocleous, Constantinos T
AU  - Sofocleous CT
FAU - Getrajdman, George I
AU  - Getrajdman GI
FAU - Brody, Lynn A
AU  - Brody LA
FAU - Thornton, Raymond H
AU  - Thornton RH
FAU - Maybody, Majid
AU  - Maybody M
FAU - Covey, Ann M
AU  - Covey AM
FAU - Siegelbaum, Robert H
AU  - Siegelbaum RH
FAU - Alago, William
AU  - Alago W
FAU - Solomon, Stephen B
AU  - Solomon SB
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20121114
PL  - United States
TA  - Cardiovasc Intervent Radiol
JT  - Cardiovascular and interventional radiology
JID - 8003538
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*diagnostic imaging/mortality/*therapy
MH  - Chemoembolization, Therapeutic/*methods
MH  - Cohort Studies
MH  - *Contrast Media
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*diagnostic imaging/mortality/*therapy
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Particle Size
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Radiographic Image Enhancement
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Time Factors
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4394653
MID - NIHMS672166
COIS- Conflict of interest Stephen B. Solomon received a research grant from GE 
      Healthcare (Milwaukee, WI).
EDAT- 2012/11/16 06:00
MHDA- 2014/03/13 06:00
PMCR- 2015/04/13
CRDT- 2012/11/16 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/09/23 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
PHST- 2015/04/13 00:00 [pmc-release]
AID - 10.1007/s00270-012-0506-x [doi]
PST - ppublish
SO  - Cardiovasc Intervent Radiol. 2013 Aug;36(4):1030-8. doi: 
      10.1007/s00270-012-0506-x. Epub 2012 Nov 14.