PMID- 2317825
OWN - NLM
STAT- MEDLINE
DCOM- 19900503
LR  - 20210108
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 50
IP  - 8
DP  - 1990 Apr 15
TI  - Microvascular architecture of experimental colon tumors in the rat.
PG  - 2411-7
AB  - Tumor cell proliferation is dependent upon concurrent growth of a supporting 
      vasculature. This study aims to characterize the structural features of the 
      microvasculature within a primary tumor model. There were 22 colon tumors induced 
      in 16 rats by repeated administration of dimethylhydrazine. A cast of the 
      microvessels was prepared by intraarterial administration of acrylic resin 
      (Mercox). After corrosion of the tissue, the cast was examined by scanning 
      electron microscopy. Tumors 2.6 to 12.0 mm in diameter were examined. Within 
      polypoid carcinomas up to 5.7 mm in diameter, there were two distinct vascular 
      zones, a luminal vascular zone continuous with the vasculature of normal mucosa 
      and a central zone continuous with the normal submucosa and muscularis propria 
      vessels. Within both vascular zones, the organization of microvessels had the 
      same general pattern as in normal mucosa. However, in tumors with diameters 
      greater than 5.7 mm, the vasculature was seen to be disorganized and of a greater 
      density than normal. In the smallest tumors, few morphological changes were seen 
      in the individual microvessels when compared to normal. However, with tumor 
      growth, there was elongation and increased diameters of the microvessels within 
      the tumor. Microvessels within the luminal zone of the tumors which could 
      definitely be traced to veins had diameters of 50 to 100 microns (compared to 12 
      to 30 microns for normal venules). Individual microvessels varied in diameter 
      along their course forming saccular dilations in places. Networks of frequently 
      anastomosing microvessels were formed. Extravasation of resin occurred from some 
      microvessels. Elongated vessels of uniform diameter which travel distances up to 
      2 mm without branching were seen and were probably arterioles. These appearances 
      indicate that there are two distinct stages of development of the vasculature 
      within primary tumors, an early phase where the tumor is supplied by the 
      preexisting host microvessels, followed by a phase of proliferation of new 
      vessels with abnormal morphological characteristics.
FAU - Skinner, S A
AU  - Skinner SA
AD  - Monash University, Department of Surgery, Alfred Hospital, Prahran, Victoria, 
      Australia.
FAU - Tutton, P J
AU  - Tutton PJ
FAU - O'Brien, P E
AU  - O'Brien PE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Dimethylhydrazines)
SB  - IM
MH  - Adenocarcinoma/*blood supply/chemically induced/ultrastructure
MH  - Animals
MH  - Colon/blood supply/ultrastructure
MH  - Colonic Neoplasms/*blood supply/chemically induced/ultrastructure
MH  - Dimethylhydrazines
MH  - Male
MH  - Microcirculation/*ultrastructure
MH  - Microscopy, Electron, Scanning
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1990/04/15 00:00
MHDA- 1990/04/15 00:01
CRDT- 1990/04/15 00:00
PHST- 1990/04/15 00:00 [pubmed]
PHST- 1990/04/15 00:01 [medline]
PHST- 1990/04/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1990 Apr 15;50(8):2411-7.