PMID- 23241654
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1748-3395 (Electronic)
IS  - 1748-3387 (Print)
IS  - 1748-3387 (Linking)
VI  - 8
IP  - 1
DP  - 2013 Jan
TI  - Synthetic nanoparticles functionalized with biomimetic leukocyte membranes 
      possess cell-like functions.
PG  - 61-8
LID - 10.1038/nnano.2012.212 [doi]
AB  - The therapeutic efficacy of systemic drug-delivery vehicles depends on their 
      ability to evade the immune system, cross the biological barriers of the body and 
      localize at target tissues. White blood cells of the immune system--known as 
      leukocytes--possess all of these properties and exert their targeting ability 
      through cellular membrane interactions. Here, we show that nanoporous silicon 
      particles can successfully perform all these actions when they are coated with 
      cellular membranes purified from leukocytes. These hybrid particles, called 
      leukolike vectors, can avoid being cleared by the immune system. Furthermore, 
      they can communicate with endothelial cells through receptor-ligand interactions, 
      and transport and release a payload across an inflamed reconstructed endothelium. 
      Moreover, leukolike vectors retained their functions when injected in vivo, 
      showing enhanced circulation time and improved accumulation in a tumour.
FAU - Parodi, Alessandro
AU  - Parodi A
AD  - Department of Nanomedicine, The Methodist Hospital System Research Institute, 
      Houston, Texas 77030, USA.
FAU - Quattrocchi, Nicoletta
AU  - Quattrocchi N
FAU - van de Ven, Anne L
AU  - van de Ven AL
FAU - Chiappini, Ciro
AU  - Chiappini C
FAU - Evangelopoulos, Michael
AU  - Evangelopoulos M
FAU - Martinez, Jonathan O
AU  - Martinez JO
FAU - Brown, Brandon S
AU  - Brown BS
FAU - Khaled, Sm Z
AU  - Khaled SZ
FAU - Yazdi, Iman K
AU  - Yazdi IK
FAU - Enzo, Maria Vittoria
AU  - Enzo MV
FAU - Isenhart, Lucas
AU  - Isenhart L
FAU - Ferrari, Mauro
AU  - Ferrari M
FAU - Tasciotti, Ennio
AU  - Tasciotti E
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - U54 CA151668/CA/NCI NIH HHS/United States
GR  - U54CA151668/CA/NCI NIH HHS/United States
GR  - U54 CA143837/CA/NCI NIH HHS/United States
GR  - TL1 RR024147/RR/NCRR NIH HHS/United States
GR  - U54CA143837/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121216
PL  - England
TA  - Nat Nanotechnol
JT  - Nature nanotechnology
JID - 101283273
RN  - 0 (Membranes, Artificial)
SB  - IM
CIN - Nanomedicine (Lond). 2014 Jan;9(1):17-20. PMID: 24354812
MH  - Animals
MH  - Biological Transport
MH  - Biomimetics/*methods
MH  - Cell Adhesion
MH  - Endothelium, Vascular/cytology/metabolism
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Leukocytes/*chemistry/metabolism
MH  - Liver/chemistry/metabolism
MH  - Liver Neoplasms, Experimental/chemistry/metabolism
MH  - *Membranes, Artificial
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Models, Biological
MH  - Nanoparticles/*chemistry
MH  - Phagocytosis
PMC - PMC3751189
MID - NIHMS494926
COIS- The authors declare competing financial interests.
EDAT- 2012/12/18 06:00
MHDA- 2013/05/29 06:00
PMCR- 2013/08/23
CRDT- 2012/12/18 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PHST- 2013/08/23 00:00 [pmc-release]
AID - nnano.2012.212 [pii]
AID - 10.1038/nnano.2012.212 [doi]
PST - ppublish
SO  - Nat Nanotechnol. 2013 Jan;8(1):61-8. doi: 10.1038/nnano.2012.212. Epub 2012 Dec 
      16.