PMID- 23370778
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20220409
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Linking)
VI  - 70
IP  - 19
DP  - 2013 Oct
TI  - Biomarkers for predicting future metastasis of human gastrointestinal tumors.
PG  - 3631-56
LID - 10.1007/s00018-013-1266-8 [doi]
AB  - The recent advances in surgery and radiation therapy have significantly improved 
      the prognosis of patients with primary cancer, and the major challenge of cancer 
      treatment now is metastatic disease development. The 5-year survival rate of 
      cancer patients who have distant metastasis at diagnosis is extremely low, 
      suggesting that prediction and early detection of metastasis would definitely 
      improve their prognosis because suitable patient therapeutic management and 
      treatment strategy can be provided. Cancer cells from a primary site give rise to 
      a metastatic tumor via a number of steps which require the involvement and 
      altered expression of many regulators. These regulators may serve as biomarkers 
      for predicting metastasis. Over the past few years, numerous regulators have been 
      found correlating with metastasis. In this review, we summarize the findings of a 
      number of potential biomarkers that are involved in cadherin-catenin interaction, 
      integrin signaling, PI3K/Akt/mTOR signaling and cancer stem cell identification 
      in gastrointestinal cancers. We will also discuss how certain biomarkers are 
      associated with the tumor microenvironment that favors cancer metastasis.
FAU - Ng, Lui
AU  - Ng L
AD  - Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong 
      SAR, China, luing@hku.hk.
FAU - Poon, Ronnie Tung Ping
AU  - Poon RT
FAU - Pang, Roberta
AU  - Pang R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130131
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/*metabolism
MH  - Early Detection of Cancer/methods
MH  - Gastrointestinal Neoplasms/*metabolism/*pathology
MH  - Humans
MH  - Neoplasm Metastasis
MH  - Tumor Microenvironment/physiology
EDAT- 2013/02/02 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/02/02 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2013/01/10 00:00 [accepted]
PHST- 2013/01/02 00:00 [revised]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1007/s00018-013-1266-8 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2013 Oct;70(19):3631-56. doi: 10.1007/s00018-013-1266-8. Epub 
      2013 Jan 31.