PMID- 23398152
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20220310
IS  - 1545-1585 (Electronic)
IS  - 0066-4278 (Linking)
VI  - 75
DP  - 2013
TI  - Paneth cells: maestros of the small intestinal crypts.
PG  - 289-311
LID - 10.1146/annurev-physiol-030212-183744 [doi]
AB  - Paneth cells are highly specialized epithelial cells of the small intestine, 
      where they coordinate many physiological functions. First identified more than a 
      century ago on the basis of their readily discernible secretory granules by 
      routine histology, these cells are located at the base of the crypts of 
      Lieberkuhn, tiny invaginations that line the mucosal surface all along the small 
      intestine. Investigations over the past several decades determined that these 
      cells synthesize and secrete substantial quantities of antimicrobial peptides and 
      proteins. More recent studies have determined that these antimicrobial molecules 
      are key mediators of host-microbe interactions, including homeostatic balance 
      with colonizing microbiota and innate immune protection from enteric pathogens. 
      Perhaps more intriguing, Paneth cells secrete factors that help sustain and 
      modulate the epithelial stem and progenitor cells that cohabitate in the crypts 
      and rejuvenate the small intestinal epithelium. Dysfunction of Paneth cell 
      biology contributes to the pathogenesis of chronic inflammatory bowel disease.
FAU - Clevers, Hans C
AU  - Clevers HC
AD  - Hubrecht Institute-KNAW, University Medical Center Utrecht, Uppsalalaan, Utrecht 
      3584CT, The Netherlands. h.clevers@hubrecht.eu
FAU - Bevins, Charles L
AU  - Bevins CL
LA  - eng
GR  - R01 AI032738/AI/NIAID NIH HHS/United States
GR  - R01 AI050843/AI/NIAID NIH HHS/United States
GR  - R21 AI099519/AI/NIAID NIH HHS/United States
GR  - R37 AI032738/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Physiol
JT  - Annual review of physiology
JID - 0370600
RN  - 0 (Antimicrobial Cationic Peptides)
SB  - IM
MH  - Animals
MH  - Antimicrobial Cationic Peptides/physiology
MH  - Humans
MH  - Immunity, Innate/physiology
MH  - Inflammatory Bowel Diseases/etiology/physiopathology
MH  - Intestinal Mucosa/*physiology
MH  - Intestine, Small/*physiology
MH  - Metagenome/physiology
MH  - Mice
MH  - Paneth Cells/*physiology
EDAT- 2013/02/13 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/02/13 06:00
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.1146/annurev-physiol-030212-183744 [doi]
PST - ppublish
SO  - Annu Rev Physiol. 2013;75:289-311. doi: 10.1146/annurev-physiol-030212-183744.