PMID- 23406670
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20130214
IS  - 1521-0081 (Electronic)
IS  - 0031-6997 (Linking)
VI  - 65
IP  - 2
DP  - 2013 Apr
TI  - The expanding roles of Gbetagamma subunits in G protein-coupled receptor signaling and 
      drug action.
PG  - 545-77
LID - 10.1124/pr.111.005603 [doi]
AB  - Gbetagamma subunits from heterotrimeric G proteins perform a vast array of functions in 
      cells with respect to signaling, often independently as well as in concert with 
      Galpha subunits. However, the eponymous term "Gbetagamma" does not do justice to the fact 
      that 5 Gbeta and 12 Ggamma isoforms have evolved in mammals to serve much broader roles 
      beyond their canonical roles in cellular signaling. We explore the phylogenetic 
      diversity of Gbetagamma subunits with a view toward understanding these expanded roles 
      in different cellular organelles. We suggest that the particular content of 
      distinct Gbetagamma subunits regulates cellular activity, and that the granularity of 
      individual Gbeta and Ggamma action is only beginning to be understood. Given the 
      therapeutic potential of targeting Gbetagamma action, this larger view serves as a 
      prelude to more specific development of drugs aimed at individual isoforms.
FAU - Khan, Shahriar M
AU  - Khan SM
AD  - Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade 
      Sir-William-Osler, Room 1303, Montreal, Quebec H3G 1Y6, Canada.
FAU - Sleno, Rory
AU  - Sleno R
FAU - Gora, Sarah
AU  - Gora S
FAU - Zylbergold, Peter
AU  - Zylbergold P
FAU - Laverdure, Jean-Philippe
AU  - Laverdure JP
FAU - Labbe, Jean-Claude
AU  - Labbe JC
FAU - Miller, Gregory J
AU  - Miller GJ
FAU - Hebert, Terence E
AU  - Hebert TE
LA  - eng
GR  - MOP-79354/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130213
PL  - United States
TA  - Pharmacol Rev
JT  - Pharmacological reviews
JID - 0421737
RN  - 0 (G-protein Beta gamma)
RN  - 0 (GTP-Binding Protein beta Subunits)
RN  - 0 (GTP-Binding Protein gamma Subunits)
RN  - 0 (Small Molecule Libraries)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Drug Discovery
MH  - GTP-Binding Protein beta Subunits/chemistry/genetics/metabolism/*physiology
MH  - GTP-Binding Protein gamma Subunits/chemistry/genetics/metabolism/*physiology
MH  - Humans
MH  - Models, Molecular
MH  - Organelles/drug effects/metabolism
MH  - Phylogeny
MH  - *Signal Transduction/drug effects
MH  - *Small Molecule Libraries/pharmacology
MH  - Species Specificity
EDAT- 2013/02/15 06:00
MHDA- 2013/08/02 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - 65/2/545 [pii]
AID - 10.1124/pr.111.005603 [doi]
PST - epublish
SO  - Pharmacol Rev. 2013 Feb 13;65(2):545-77. doi: 10.1124/pr.111.005603. Print 2013 
      Apr.