PMID- 23484853
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20220408
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 24
IP  - 5
DP  - 2013 Mar 11
TI  - Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family 
      proteins.
PG  - 459-71
LID - S1534-5807(13)00068-3 [pii]
LID - 10.1016/j.devcel.2013.01.020 [doi]
AB  - EGFR and Hippo signaling pathways both control growth and, when dysregulated, 
      contribute to tumorigenesis. We find that EGFR activates the Hippo pathway 
      transcription factor Yorkie and demonstrate that Yorkie is required for the 
      influence of EGFR on cell proliferation in Drosophila. EGFR regulates Yorkie 
      through the influence of its Ras-MAPK branch on the Ajuba LIM protein Jub. Jub is 
      epistatic to EGFR and Ras for Yorkie regulation, Jub is subject to MAPK-dependent 
      phosphorylation, and EGFR-Ras-MAPK signaling enhances Jub binding to the Yorkie 
      kinase Warts and the adaptor protein Salvador. An EGFR-Hippo pathway link is 
      conserved in mammals, as activation of EGFR or RAS activates the Yorkie homolog 
      YAP, and EGFR-RAS-MAPK signaling promotes phosphorylation of the Ajuba family 
      protein WTIP and also enhances WTIP binding to the Warts and Salvador homologs 
      LATS and WW45. Our observations implicate the Hippo pathway in EGFR-mediated 
      tumorigenesis and identify a molecular link between these pathways.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Reddy, B V V G
AU  - Reddy BV
AD  - Howard Hughes Medical Institute, Rutgers, The State University of New Jersey, 
      Piscataway, NJ 08854, USA.
FAU - Irvine, Kenneth D
AU  - Irvine KD
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 GM078620/GM/NIGMS NIH HHS/United States
GR  - R01GM078620/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (Drosophila Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Invertebrate Peptide)
RN  - 0 (Trans-Activators)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - 0 (jub protein, Drosophila)
RN  - 0 (ras protein, Dictyostelium)
RN  - EC 2.7.10.1 (Egfr protein, Drosophila)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Drosophila Proteins/antagonists & inhibitors/genetics/*metabolism
MH  - Drosophila melanogaster/chemistry/genetics/*metabolism
MH  - ErbB Receptors/antagonists & inhibitors/genetics/*metabolism
MH  - Immunoprecipitation
MH  - LIM Domain Proteins/genetics/*metabolism
MH  - Nuclear Proteins/antagonists & inhibitors/genetics/*metabolism
MH  - RNA, Messenger/genetics
MH  - RNA, Small Interfering/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Invertebrate Peptide/antagonists & inhibitors/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Signal Transduction
MH  - Trans-Activators/antagonists & inhibitors/genetics/*metabolism
MH  - YAP-Signaling Proteins
MH  - ras Proteins/genetics/*metabolism
PMC - PMC3624988
MID - NIHMS458030
EDAT- 2013/03/15 06:00
MHDA- 2013/05/08 06:00
PMCR- 2013/09/11
CRDT- 2013/03/15 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2012/12/22 00:00 [revised]
PHST- 2013/01/23 00:00 [accepted]
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
PHST- 2013/09/11 00:00 [pmc-release]
AID - S1534-5807(13)00068-3 [pii]
AID - 10.1016/j.devcel.2013.01.020 [doi]
PST - ppublish
SO  - Dev Cell. 2013 Mar 11;24(5):459-71. doi: 10.1016/j.devcel.2013.01.020.