PMID- 23539594
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20240104
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 339
IP  - 6127
DP  - 2013 Mar 29
TI  - Cancer genome landscapes.
PG  - 1546-58
LID - 10.1126/science.1235122 [doi]
AB  - Over the past decade, comprehensive sequencing efforts have revealed the genomic 
      landscapes of common forms of human cancer. For most cancer types, this landscape 
      consists of a small number of "mountains" (genes altered in a high percentage of 
      tumors) and a much larger number of "hills" (genes altered infrequently). To 
      date, these studies have revealed ~140 genes that, when altered by intragenic 
      mutations, can promote or "drive" tumorigenesis. A typical tumor contains two to 
      eight of these "driver gene" mutations; the remaining mutations are passengers 
      that confer no selective growth advantage. Driver genes can be classified into 12 
      signaling pathways that regulate three core cellular processes: cell fate, cell 
      survival, and genome maintenance. A better understanding of these pathways is one 
      of the most pressing needs in basic cancer research. Even now, however, our 
      knowledge of cancer genomes is sufficient to guide the development of more 
      effective approaches for reducing cancer morbidity and mortality.
FAU - Vogelstein, Bert
AU  - Vogelstein B
AD  - The Ludwig Center and The Howard Hughes Medical Institute at Johns Hopkins Kimmel 
      Cancer Center, Baltimore, MD 21287, USA.
FAU - Papadopoulos, Nickolas
AU  - Papadopoulos N
FAU - Velculescu, Victor E
AU  - Velculescu VE
FAU - Zhou, Shibin
AU  - Zhou S
FAU - Diaz, Luis A Jr
AU  - Diaz LA Jr
FAU - Kinzler, Kenneth W
AU  - Kinzler KW
LA  - eng
GR  - R37 CA043460/CA/NCI NIH HHS/United States
GR  - P50 CA062924/CA/NCI NIH HHS/United States
GR  - CA 121113/CA/NCI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 CA121113/CA/NCI NIH HHS/United States
GR  - CA 43460/CA/NCI NIH HHS/United States
GR  - CA 62924/CA/NCI NIH HHS/United States
GR  - R37 CA057345/CA/NCI NIH HHS/United States
GR  - R01 CA057345/CA/NCI NIH HHS/United States
GR  - CA 47345/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Cell Transformation, Neoplastic/*genetics
MH  - *Genes, Neoplasm
MH  - Genetic Heterogeneity
MH  - *Genome, Human
MH  - Humans
MH  - *Mutagenesis
MH  - Mutation
MH  - Neoplasms/*genetics
MH  - Signal Transduction/genetics
PMC - PMC3749880
MID - NIHMS496129
EDAT- 2013/03/30 06:00
MHDA- 2013/04/04 06:00
PMCR- 2013/08/22
CRDT- 2013/03/30 06:00
PHST- 2013/03/30 06:00 [entrez]
PHST- 2013/03/30 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
PHST- 2013/08/22 00:00 [pmc-release]
AID - 339/6127/1546 [pii]
AID - 10.1126/science.1235122 [doi]
PST - ppublish
SO  - Science. 2013 Mar 29;339(6127):1546-58. doi: 10.1126/science.1235122.