PMID- 23550210
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20241219
IS  - 1937-9145 (Electronic)
IS  - 1945-0877 (Linking)
VI  - 6
IP  - 269
DP  - 2013 Apr 2
TI  - Integrative analysis of complex cancer genomics and clinical profiles using the 
      cBioPortal.
PG  - pl1
LID - 10.1126/scisignal.2004088 [doi]
AB  - The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web 
      resource for exploring, visualizing, and analyzing multidimensional cancer 
      genomics data. The portal reduces molecular profiling data from cancer tissues 
      and cell lines into readily understandable genetic, epigenetic, gene expression, 
      and proteomic events. The query interface combined with customized data storage 
      enables researchers to interactively explore genetic alterations across samples, 
      genes, and pathways and, when available in the underlying data, to link these to 
      clinical outcomes. The portal provides graphical summaries of gene-level data 
      from multiple platforms, network visualization and analysis, survival analysis, 
      patient-centric queries, and software programmatic access. The intuitive Web 
      interface of the portal makes complex cancer genomics profiles accessible to 
      researchers and clinicians without requiring bioinformatics expertise, thus 
      facilitating biological discoveries. Here, we provide a practical guide to the 
      analysis and visualization features of the cBioPortal for Cancer Genomics.
FAU - Gao, Jianjiong
AU  - Gao J
AD  - Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, 
      NY 10065, USA.
FAU - Aksoy, Bulent Arman
AU  - Aksoy BA
FAU - Dogrusoz, Ugur
AU  - Dogrusoz U
FAU - Dresdner, Gideon
AU  - Dresdner G
FAU - Gross, Benjamin
AU  - Gross B
FAU - Sumer, S Onur
AU  - Sumer SO
FAU - Sun, Yichao
AU  - Sun Y
FAU - Jacobsen, Anders
AU  - Jacobsen A
FAU - Sinha, Rileen
AU  - Sinha R
FAU - Larsson, Erik
AU  - Larsson E
FAU - Cerami, Ethan
AU  - Cerami E
FAU - Sander, Chris
AU  - Sander C
FAU - Schultz, Nikolaus
AU  - Schultz N
LA  - eng
GR  - U24CA143840/CA/NCI NIH HHS/United States
GR  - P41 RR031228/RR/NCRR NIH HHS/United States
GR  - R01 CA132744/CA/NCI NIH HHS/United States
GR  - P41 GM103504/GM/NIGMS NIH HHS/United States
GR  - R21 CA135870/CA/NCI NIH HHS/United States
GR  - U24 CA143840/CA/NCI NIH HHS/United States
GR  - GM103504/GM/NIGMS NIH HHS/United States
GR  - R21CA135870/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130402
PL  - United States
TA  - Sci Signal
JT  - Science signaling
JID - 101465400
SB  - IM
MH  - *Gene Expression Profiling
MH  - *Gene Regulatory Networks
MH  - Genetic Predisposition to Disease/*genetics
MH  - *Genomics
MH  - Humans
MH  - Information Storage and Retrieval/*methods
MH  - Internet
MH  - Neoplasms/*genetics/pathology
MH  - Reproducibility of Results
MH  - Software
PMC - PMC4160307
MID - NIHMS622586
COIS- Competing interests: The authors declare that they have no competing interests.
EDAT- 2013/04/04 06:00
MHDA- 2013/09/24 06:00
PMCR- 2014/09/10
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
PHST- 2014/09/10 00:00 [pmc-release]
AID - scisignal.2004088 [pii]
AID - 10.1126/scisignal.2004088 [doi]
PST - epublish
SO  - Sci Signal. 2013 Apr 2;6(269):pl1. doi: 10.1126/scisignal.2004088.