PMID- 23587490 OWN - NLM STAT- MEDLINE DCOM- 20140124 LR - 20130701 IS - 1879-3088 (Electronic) IS - 0962-8924 (Linking) VI - 23 IP - 7 DP - 2013 Jul TI - Coordination of organ growth: principles and outstanding questions from the world of insects. PG - 336-44 LID - S0962-8924(13)00049-4 [pii] LID - 10.1016/j.tcb.2013.03.005 [doi] AB - In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size. CI - Copyright (c) 2013 Elsevier Ltd. All rights reserved. FAU - Andersen, D S AU - Andersen DS AD - University of Nice-Sophia Antipolis, CNRS, and INSERM, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France. FAU - Colombani, J AU - Colombani J FAU - Leopold, P AU - Leopold P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20130412 PL - England TA - Trends Cell Biol JT - Trends in cell biology JID - 9200566 RN - 0 (Drosophila Proteins) RN - 3604-87-3 (Ecdysone) SB - IM MH - Animals MH - Drosophila/*growth & development/metabolism MH - Drosophila Proteins/metabolism/*physiology MH - Ecdysone/metabolism/*physiology MH - Fat Body/growth & development/metabolism MH - Imaginal Discs/growth & development/metabolism MH - Larva/growth & development/metabolism MH - Models, Biological MH - Signal Transduction/*physiology EDAT- 2013/04/17 06:00 MHDA- 2014/01/25 06:00 CRDT- 2013/04/17 06:00 PHST- 2013/01/02 00:00 [received] PHST- 2013/03/13 00:00 [revised] PHST- 2013/03/14 00:00 [accepted] PHST- 2013/04/17 06:00 [entrez] PHST- 2013/04/17 06:00 [pubmed] PHST- 2014/01/25 06:00 [medline] AID - S0962-8924(13)00049-4 [pii] AID - 10.1016/j.tcb.2013.03.005 [doi] PST - ppublish SO - Trends Cell Biol. 2013 Jul;23(7):336-44. doi: 10.1016/j.tcb.2013.03.005. Epub 2013 Apr 12.