PMID- 23640210
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20211021
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 13
IP  - 6
DP  - 2013 Jun
TI  - The emerging mutational landscape of G proteins and G-protein-coupled receptors 
      in cancer.
PG  - 412-24
LID - 10.1038/nrc3521 [doi]
AB  - Aberrant expression and activity of G proteins and G-protein-coupled receptors 
      (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies 
      show that 4.2% of tumours carry activating mutations in GNAS (encoding Galphas), and 
      that oncogenic activating mutations in genes encoding Galphaq family members (GNAQ or 
      GNA11) are present in ~66% and ~6% of melanomas arising in the eye and skin, 
      respectively. Furthermore, nearly 20% of human tumours harbour mutations in 
      GPCRs. Many human cancer-associated viruses also express constitutively active 
      viral GPCRs. These studies indicate that G proteins, GPCRs and their linked 
      signalling circuitry represent novel therapeutic targets for cancer prevention 
      and treatment.
FAU - O'Hayre, Morgan
AU  - O'Hayre M
AD  - Oral and Pharyngeal Cancer Branch, Dental and Craniofacial Research, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Vazquez-Prado, Jose
AU  - Vazquez-Prado J
FAU - Kufareva, Irina
AU  - Kufareva I
FAU - Stawiski, Eric W
AU  - Stawiski EW
FAU - Handel, Tracy M
AU  - Handel TM
FAU - Seshagiri, Somasekar
AU  - Seshagiri S
FAU - Gutkind, J Silvio
AU  - Gutkind JS
LA  - eng
GR  - U54 GM094618/GM/NIGMS NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - R01 HD038718/HD/NICHD NIH HHS/United States
GR  - R01 GM071872/GM/NIGMS NIH HHS/United States
GR  - U01 GM094612/GM/NIGMS NIH HHS/United States
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130503
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - EC 3.6.5.1 (Heterotrimeric GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - Gene Frequency
MH  - Heterotrimeric GTP-Binding Proteins/*genetics/metabolism
MH  - Humans
MH  - Mutation
MH  - Neoplasms/genetics/*metabolism
MH  - Receptors, G-Protein-Coupled/*genetics/metabolism
MH  - Signal Transduction
PMC - PMC4068741
MID - NIHMS591342
EDAT- 2013/05/04 06:00
MHDA- 2013/07/24 06:00
PMCR- 2014/06/24
CRDT- 2013/05/04 06:00
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
PHST- 2014/06/24 00:00 [pmc-release]
AID - nrc3521 [pii]
AID - 10.1038/nrc3521 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2013 Jun;13(6):412-24. doi: 10.1038/nrc3521. Epub 2013 May 3.