PMID- 23665236
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20211203
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 45
IP  - 8
DP  - 2013 Aug
TI  - EVI1 targets DeltaNp63 and upregulates the cyclin dependent kinase inhibitor p21 
      independent of p53 to delay cell cycle progression and cell proliferation in 
      colon cancer cells.
PG  - 1568-76
LID - S1357-2725(13)00137-4 [pii]
LID - 10.1016/j.biocel.2013.04.032 [doi]
AB  - Several lines of evidence suggest that specific transcriptional events are 
      involved in cell cycle, proliferation and differentiation processes; however, 
      their deregulation by proto-oncogenes are involved in the development of leukemia 
      and tumors. One such proto-oncogene is ecotropic viral integration site I which 
      can differentially effect cell cycle progression and proliferation, in cell types 
      of different origin. Our data for the first time shows that ecotropic viral 
      integration site I binds to DeltaNp63 promoter element directly and down regulates 
      its expression. Down regulation of DeltaNp63 induces the expression of p21 in HT-29 
      cells and also in colon carcinoma cells that do not express p53 including patient 
      samples expressing low level of p53, that eventually delay cell cycle progression 
      at G0/G1 phase. Concomitant silencing of ecotropic viral integration site I from 
      the cells or introduction of DeltaNp63 to the cells significantly rescued this 
      phenotype, indicating the growth defect induced by DeltaNp63 deficiency to be, at 
      least in part, attributable to ecotropic viral integration site I function. The 
      mutual regulation between ecotropic viral integration site I and DeltaNp63 may 
      constitute a novel axis which might affect the downstream pathways in cells that 
      do not express functional p53.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Nayak, Kasturi Bala
AU  - Nayak KB
AD  - Department of Gene Function and Regulation, Institute of Life Sciences, Nalco 
      Square, Bhubaneswar, Odisha, India.
FAU - Kuila, Nivedita
AU  - Kuila N
FAU - Das Mohapatra, Alok
AU  - Das Mohapatra A
FAU - Panda, Aditya K
AU  - Panda AK
FAU - Chakraborty, Soumen
AU  - Chakraborty S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130509
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAS1 protein, human)
RN  - 0 (MDS1 and EVI1 Complex Locus Protein)
RN  - 0 (MECOM protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (TP63 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Base Sequence
MH  - *Cell Cycle
MH  - Cell Proliferation
MH  - Colonic Neoplasms/genetics/*pathology
MH  - Cyclin-Dependent Kinase Inhibitor p21/*genetics
MH  - DNA-Binding Proteins/chemistry/*metabolism
MH  - Down-Regulation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Silencing
MH  - HCT116 Cells
MH  - HEK293 Cells
MH  - HT29 Cells
MH  - Humans
MH  - MDS1 and EVI1 Complex Locus Protein
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Binding/genetics
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogenes
MH  - Transcription Factors/chemistry/*metabolism
MH  - Transcription, Genetic
MH  - Tumor Suppressor Protein p53/deficiency/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
MH  - Up-Regulation/*genetics
MH  - Zinc Fingers
OTO - NOTNLM
OT  - Cell cycle
OT  - Colon cancer
OT  - EVI1
OT  - p21
OT  - DeltaNp63
EDAT- 2013/05/15 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/03/20 00:00 [received]
PHST- 2013/04/15 00:00 [revised]
PHST- 2013/04/29 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - S1357-2725(13)00137-4 [pii]
AID - 10.1016/j.biocel.2013.04.032 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2013 Aug;45(8):1568-76. doi: 
      10.1016/j.biocel.2013.04.032. Epub 2013 May 9.