PMID- 23812590
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20211021
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 500
IP  - 7460
DP  - 2013 Aug 1
TI  - Dual-mode operation of neuronal networks involved in left-right alternation.
PG  - 85-8
LID - 10.1038/nature12286 [doi]
AB  - All forms of locomotion are repetitive motor activities that require coordinated 
      bilateral activation of muscles. The executive elements of locomotor control are 
      networks of spinal neurons that determine gait pattern through the sequential 
      activation of motor-neuron pools on either side of the body axis. However, little 
      is known about the constraints that link left-right coordination to locomotor 
      speed. Recent advances have indicated that both excitatory and inhibitory 
      commissural neurons may be involved in left-right coordination. But the neural 
      underpinnings of this, and a possible causal link between these different groups 
      of commissural neurons and left-right alternation, are lacking. Here we show, 
      using intersectional mouse genetics, that ablation of a group of 
      transcriptionally defined commissural neurons--the V0 population--leads to a 
      quadrupedal hopping at all frequencies of locomotion. The selective ablation of 
      inhibitory V0 neurons leads to a lack of left-right pattern at low frequencies, 
      mixed coordination at medium frequencies, and alternation at high locomotor 
      frequencies. When ablation is targeted to excitatory V0 neurons, left-right 
      alternation is present at low frequencies, and hopping is restricted to medium 
      and high locomotor frequencies. Therefore, the intrinsic logic of the central 
      control of locomotion incorporates a modular organization, with two subgroups of 
      V0 neurons required for the existence of left-right alternating modes at 
      different speeds of locomotion. The two molecularly distinct sets of commissural 
      neurons may constrain species-related naturally occurring frequency-dependent 
      coordination and be involved in the evolution of different gaits.
FAU - Talpalar, Adolfo E
AU  - Talpalar AE
AD  - The Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska 
      Institutet, Stockholm S-17177, Sweden.
FAU - Bouvier, Julien
AU  - Bouvier J
FAU - Borgius, Lotta
AU  - Borgius L
FAU - Fortin, Gilles
AU  - Fortin G
FAU - Pierani, Alessandra
AU  - Pierani A
FAU - Kiehn, Ole
AU  - Kiehn O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130630
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Dbx1 protein, mouse)
RN  - 0 (Homeodomain Proteins)
SB  - IM
CIN - Curr Biol. 2013 Sep 9;23(17):R716-8. PMID: 24028949
MH  - Animals
MH  - Extremities/*physiology
MH  - Functional Laterality/genetics/*physiology
MH  - Gait/genetics/physiology
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Locomotion/genetics/*physiology
MH  - Mice
MH  - Nerve Net/*physiology
MH  - Neural Inhibition
MH  - Neurons/*physiology
MH  - Spinal Nerves/cytology/physiology
EDAT- 2013/07/03 06:00
MHDA- 2013/09/14 06:00
CRDT- 2013/07/02 06:00
PHST- 2012/10/11 00:00 [received]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - nature12286 [pii]
AID - 10.1038/nature12286 [doi]
PST - ppublish
SO  - Nature. 2013 Aug 1;500(7460):85-8. doi: 10.1038/nature12286. Epub 2013 Jun 30.