PMID- 2384160
OWN - NLM
STAT- MEDLINE
DCOM- 19900920
LR  - 20220317
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 268
IP  - 1
DP  - 1990 Jul 30
TI  - Amphipathic polyethyleneglycols effectively prolong the circulation time of 
      liposomes.
PG  - 235-7
AB  - Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol 
      succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes 
      composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly 
      increase the content leakage when the liposomes are exposed to 90% human serum at 
      37 degrees C, yet the liposomes show a significant increase in the blood 
      circulation half-life (t1/2 = 5 h) as compared to those without PEG-PE(t1/2 less 
      than 30 min). The PEG-PE's activity to prolong the circulation time of liposomes 
      is greater than that of the ganglioside GM1, a well-described glycolipid with 
      this activity. Another amphipathic PEG derivative, PEG stearate, also prolongs 
      the liposome circulation time, although its activity is less than that of GM1. 
      Amphipathic PEGs may be useful for the sustained release and the targeted drug 
      delivery by liposomes.
FAU - Klibanov, A L
AU  - Klibanov AL
AD  - Department of Biochemistry, University of Tennessee, Knoxville 37996-0840.
FAU - Maruyama, K
AU  - Maruyama K
FAU - Torchilin, V P
AU  - Torchilin VP
FAU - Huang, L
AU  - Huang L
LA  - eng
GR  - AI 25834/AI/NIAID NIH HHS/United States
GR  - CA 24553/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Liposomes)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Animals
MH  - Humans
MH  - In Vitro Techniques
MH  - Liposomes/*pharmacokinetics
MH  - Liver/metabolism
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Permeability
MH  - *Polyethylene Glycols
MH  - Spleen/metabolism
EDAT- 1990/07/30 00:00
MHDA- 1990/07/30 00:01
CRDT- 1990/07/30 00:00
PHST- 1990/07/30 00:00 [pubmed]
PHST- 1990/07/30 00:01 [medline]
PHST- 1990/07/30 00:00 [entrez]
AID - 0014-5793(90)81016-H [pii]
AID - 10.1016/0014-5793(90)81016-h [doi]
PST - ppublish
SO  - FEBS Lett. 1990 Jul 30;268(1):235-7. doi: 10.1016/0014-5793(90)81016-h.