PMID- 23864876
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20211021
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2013
DP  - 2013
TI  - Microglia and macrophages in malignant gliomas: recent discoveries and 
      implications for promising therapies.
PG  - 264124
LID - 10.1155/2013/264124 [doi]
LID - 264124
AB  - Malignant gliomas are the most common primary brain tumors. Their deadliest 
      manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary 
      brain tumors and is associated with a median survival of only 15 months even 
      after multimodal therapy. There is substantial presence of microglia and 
      macrophages within and surrounding brain tumors. These immune cells acquire an 
      alternatively activated phenotype with potent tumor-tropic functions that 
      contribute to glioma growth and invasion. In this review, we briefly summarize 
      recent data that has been reported on the interaction of microglia/macrophages 
      with brain tumors and discuss potential application of these findings to the 
      development of future antiglioma therapies.
FAU - da Fonseca, Anna Carolina Carvalho
AU  - da Fonseca AC
AD  - Laboratorio de Morfogenese Celular, Instituto de Ciencias Biomedicas, 
      Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Badie, Behnam
AU  - Badie B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130625
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (Antibodies)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Integrin alpha5beta1)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology/therapeutic use
MH  - Brain Neoplasms/drug therapy/*immunology/pathology
MH  - Cell Communication/drug effects/immunology
MH  - Chemokine CCL2/antagonists & inhibitors/genetics/immunology
MH  - Chemotaxis/drug effects/immunology
MH  - Glioma/drug therapy/*immunology/pathology
MH  - Humans
MH  - Integrin alpha5beta1/antagonists & inhibitors/genetics/immunology
MH  - Macrophages/drug effects/*immunology/pathology
MH  - Microglia/drug effects/*immunology/pathology
MH  - RNA, Small Interfering/genetics/immunology/therapeutic use
MH  - STAT3 Transcription Factor/antagonists & inhibitors/genetics/immunology
MH  - Tumor Microenvironment/drug effects/immunology
PMC - PMC3707269
EDAT- 2013/07/19 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/06/25
CRDT- 2013/07/19 06:00
PHST- 2013/04/23 00:00 [received]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/07/19 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/06/25 00:00 [pmc-release]
AID - 10.1155/2013/264124 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2013;2013:264124. doi: 10.1155/2013/264124. Epub 2013 Jun 25.