PMID- 23870119
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20221222
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 154
IP  - 2
DP  - 2013 Jul 18
TI  - The intestinal crypt, a prototype stem cell compartment.
PG  - 274-84
LID - S0092-8674(13)00838-6 [pii]
LID - 10.1016/j.cell.2013.07.004 [doi]
AB  - Due to its intense self-renewal kinetics and its simple repetitive architecture, 
      the intestinal epithelium has become a prime model for studying adult stem cells 
      in health and disease. Transgenic mouse models allow in vivo visualization and 
      genetic lineage tracing of individual intestinal stem cells and their offspring. 
      Fluorescently marked stem cells can be isolated for molecular analyses or can be 
      cultured to build ever-expanding "mini-guts" in vitro. These studies are filling 
      in the outlines of a robust homeostatic self-renewal process that defies some of 
      the classical definitions of stem cell behavior, such as asymmetric division, 
      quiescence, and exhaustion.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Clevers, Hans
AU  - Clevers H
AD  - Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT 
      Utrecht, the Netherlands. h.clevers@hubrecht.eu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Adult Stem Cells/*cytology/*metabolism
MH  - Animals
MH  - Cell Culture Techniques
MH  - Humans
MH  - Intestinal Mucosa/*cytology/embryology/immunology/*metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Wnt Signaling Pathway
EDAT- 2013/07/23 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0092-8674(13)00838-6 [pii]
AID - 10.1016/j.cell.2013.07.004 [doi]
PST - ppublish
SO  - Cell. 2013 Jul 18;154(2):274-84. doi: 10.1016/j.cell.2013.07.004.