PMID- 23933178
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20220129
IS  - 1569-1802 (Electronic)
IS  - 0945-053X (Linking)
VI  - 32
IP  - 7-8
DP  - 2013 Oct-Nov
TI  - Review: molecular mechanism of microglia stimulated glioblastoma invasion.
PG  - 372-80
LID - S0945-053X(13)00103-0 [pii]
LID - 10.1016/j.matbio.2013.07.008 [doi]
AB  - Glioblastoma multiforme is one of the deadliest human cancers and is 
      characterized by a high degree of microglia and macrophage infiltration. The role 
      of these glioma infiltrating macrophages (GIMs) in disease progression has been 
      the subject of recent investigation. While initially thought to reflect an immune 
      response to the tumor, the balance of evidence clearly suggests GIMs can have 
      potent tumor-tropic functions and assist in glioma cell growth and infiltration 
      into normal brain. In this review, we focus on the evidence for GIMs aiding 
      mediating glioblastoma motility and invasion. We survey the literature for 
      molecular pathways that are involved in paracrine interaction between glioma 
      cells and GIMs and assess which of these might serve as attractive targets for 
      therapeutic intervention.
CI  - (c) 2013.
FAU - Coniglio, Salvatore J
AU  - Coniglio SJ
AD  - Albert Einstein College of Medicine, Department of Anatomy and Structural 
      Biology, Bronx, NY 10461, United States. Electronic address: 
      salvatore.coniglio@einstein.yu.edu.
FAU - Segall, Jeffrey E
AU  - Segall JE
LA  - eng
GR  - 11-0135/AICR_/Worldwide Cancer Research/United Kingdom
GR  - CA100324/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130807
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 0 (Cytokines)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Cytokines/metabolism
MH  - Extracellular Matrix Proteins/*metabolism
MH  - Glioblastoma/*physiopathology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Macrophages/*physiology
MH  - Microglia/*physiology
MH  - Neoplasm Invasiveness/*physiopathology
MH  - Paracrine Communication/*physiology
MH  - Peptide Hydrolases/metabolism
MH  - Signal Transduction/*physiology
OTO - NOTNLM
OT  - CSF-1R
OT  - Glioma
OT  - Invasion
OT  - MMPs
OT  - Macrophages
OT  - Microglia
OT  - TGFbeta
EDAT- 2013/08/13 06:00
MHDA- 2014/07/23 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/03/28 00:00 [received]
PHST- 2013/07/28 00:00 [revised]
PHST- 2013/07/28 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
AID - S0945-053X(13)00103-0 [pii]
AID - 10.1016/j.matbio.2013.07.008 [doi]
PST - ppublish
SO  - Matrix Biol. 2013 Oct-Nov;32(7-8):372-80. doi: 10.1016/j.matbio.2013.07.008. Epub 
      2013 Aug 7.