PMID- 23983766
OWN - NLM
STAT- MEDLINE
DCOM- 20140217
LR  - 20220223
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2013
DP  - 2013
TI  - The controversial role of microglia in malignant gliomas.
PG  - 285246
LID - 10.1155/2013/285246 [doi]
LID - 285246
AB  - Malignant gliomas contain stroma and a variety of immune cells including abundant 
      activated microglia/macrophages. Mounting evidence indicates that the glioma 
      microenvironment converts the glioma-associated microglia/macrophages (GAMs) into 
      glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic 
      anti-tumor properties. Here, we review and discuss this duality and the potential 
      therapeutic strategies that may inhibit their glioma-supportive and propagating 
      functions.
FAU - Wei, Jun
AU  - Wei J
AD  - Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030-1402, USA.
FAU - Gabrusiewicz, Konrad
AU  - Gabrusiewicz K
FAU - Heimberger, Amy
AU  - Heimberger A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130724
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/drug therapy/*immunology/*metabolism
MH  - Cell Communication
MH  - Glioma/drug therapy/*immunology/*metabolism
MH  - Humans
MH  - Macrophage Activation
MH  - Macrophages/drug effects/immunology/metabolism
MH  - Microglia/drug effects/*immunology/*metabolism
PMC - PMC3741958
EDAT- 2013/08/29 06:00
MHDA- 2014/02/18 06:00
PMCR- 2013/07/24
CRDT- 2013/08/29 06:00
PHST- 2013/04/16 00:00 [received]
PHST- 2013/06/19 00:00 [accepted]
PHST- 2013/08/29 06:00 [entrez]
PHST- 2013/08/29 06:00 [pubmed]
PHST- 2014/02/18 06:00 [medline]
PHST- 2013/07/24 00:00 [pmc-release]
AID - 10.1155/2013/285246 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2013;2013:285246. doi: 10.1155/2013/285246. Epub 2013 Jul 24.