PMID- 2399810
OWN - NLM
STAT- MEDLINE
DCOM- 19901016
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 80
IP  - 3
DP  - 1990
TI  - Monocyte subpopulations in human gliomas: expression of Fc and complement 
      receptors and correlation with tumor proliferation.
PG  - 287-94
AB  - Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were 
      investigated for mononuclear cell infiltration by immunohistochemistry, 
      concentrating on cells expressing monocyte/macrophage markers. Only low numbers 
      of T cells were detected in the tumors, whereas in average 20%-30% of all cells 
      present in the samples were recognized by various macrophage markers. These cells 
      carried surface epitopes with known function, like Fc-gamma (Fcg) and complement 
      receptors. Microglial cells, in comparison to typical debris laden macrophages, 
      were only recognized by a restricted panel of macrophages markers (anti-Fcg 
      receptors 1, 2, 3, complement receptor CR3, HLA DR, common leucocyte antigen CD45 
      and the monocyte marker RM3/1). In peritumoral tissue mainly dendritic, 
      microglia-like cells were present, which revealed decreased expression of 
      antigens CD4, RM3/1 and Fcg receptors in comparison to those in gliomas. A 
      significant positive correlation was found between the number of RM3/1 or CR3 
      (CD11b)-positive cells and the proliferation rate of the tumors as documented by 
      the number of bromodeoxyuridine-positive or Ki-67+ cells.
FAU - Morimura, T
AU  - Morimura T
AD  - Neurologisches Institut, Universitat Wien, Austria.
FAU - Neuchrist, C
AU  - Neuchrist C
FAU - Kitz, K
AU  - Kitz K
FAU - Budka, H
AU  - Budka H
FAU - Scheiner, O
AU  - Scheiner O
FAU - Kraft, D
AU  - Kraft D
FAU - Lassmann, H
AU  - Lassmann H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Complement)
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Brain Neoplasms/immunology/*pathology
MH  - Cell Division
MH  - Glioma/immunology/*pathology
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - *Leukocyte Count
MH  - Leukocytes, Mononuclear/immunology
MH  - Macrophages/immunology
MH  - Receptors, Complement/analysis
MH  - Receptors, Fc/analysis
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF00294647 [doi]
PST - ppublish
SO  - Acta Neuropathol. 1990;80(3):287-94. doi: 10.1007/BF00294647.