PMID- 24063806
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20220129
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 383
IP  - 2
DP  - 2013 Nov 15
TI  - The function of Notch signalling in segment formation in the crustacean Daphnia 
      magna (Branchiopoda).
PG  - 321-30
LID - S0012-1606(13)00506-X [pii]
LID - 10.1016/j.ydbio.2013.09.021 [doi]
AB  - Ten years ago we showed for the first time that Notch signalling is required in 
      segmentation in spiders, indicating the existence of similar mechanisms in 
      arthropod and vertebrate segmentation. However, conflicting results in various 
      arthropod groups hampered our understanding of the ancestral function of Notch in 
      arthropod segmentation. Here we fill a crucial data gap in arthropods and analyse 
      segmentation in a crustacean embryo. We analyse the expression of homologues of 
      the Drosophila and vertebrate segmentation genes and show that members of the 
      Notch signalling pathway are expressed at the same time as the pair-rule genes. 
      Furthermore, inactivation of Notch signalling results in irregular boundaries of 
      the odd-skipped-like expression domains and affects the formation of segments. In 
      severe cases embryos appear unsegmented. We suggest two scenarios for the 
      function of Notch signalling in segmentation. The first scenario agrees with a 
      segmentation clock involving Notch signalling, while the second scenario 
      discusses an alternative mechanism of Notch function which is integrated into a 
      hierarchical segmentation cascade.
CI  - (c) 2013 Elsevier Inc. All rights reserved.
FAU - Eriksson, Bo Joakim
AU  - Eriksson BJ
AD  - School of Biological and Chemical Sciences, Queen Mary University of London, Mile 
      End Road, London E1 4NS, UK; Department of Neurobiology, University of Vienna, 
      Althanstrasse 14, 1090 Vienna, Austria.
FAU - Ungerer, Petra
AU  - Ungerer P
FAU - Stollewerk, Angelika
AU  - Stollewerk A
LA  - eng
GR  - BB/F021909/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130921
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Receptors, Notch)
SB  - IM
MH  - Animals
MH  - *Body Patterning/genetics
MH  - Daphnia/*embryology/*metabolism
MH  - Drosophila melanogaster/embryology
MH  - Embryo, Nonmammalian/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Models, Biological
MH  - Receptors, Notch/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction/genetics
MH  - Spatio-Temporal Analysis
OTO - NOTNLM
OT  - Delta-Notch signalling
OT  - Hes
OT  - Pair-rule genes
OT  - Segmentation cascade
OT  - odd-skipped
OT  - snail
EDAT- 2013/09/26 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/09/11 00:00 [revised]
PHST- 2013/09/15 00:00 [accepted]
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0012-1606(13)00506-X [pii]
AID - 10.1016/j.ydbio.2013.09.021 [doi]
PST - ppublish
SO  - Dev Biol. 2013 Nov 15;383(2):321-30. doi: 10.1016/j.ydbio.2013.09.021. Epub 2013 
      Sep 21.