PMID- 24202394
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20211203
IS  - 1546-170X (Electronic)
IS  - 1078-8956 (Linking)
VI  - 19
IP  - 11
DP  - 2013 Nov
TI  - Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
PG  - 1410-22
LID - 10.1038/nm.3389 [doi]
AB  - Major progress has been made in recent years in the development of Hedgehog (Hh) 
      pathway inhibitors for the treatment of patients with cancer. Promising clinical 
      trial results have been obtained in cancers that harbor activating mutations of 
      the Hh pathway, such as basal cell carcinoma and medulloblastoma. However, for 
      many cancers, in which Hh ligand overexpression is thought to drive tumor growth, 
      results have been disappointing. Here we review the preclinical data that 
      continue to shape our understanding of the Hh pathway in tumorigenesis and the 
      emerging clinical experience with smoothened inhibitors.
FAU - Amakye, Dereck
AU  - Amakye D
AD  - Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
FAU - Jagani, Zainab
AU  - Jagani Z
FAU - Dorsch, Marion
AU  - Dorsch M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131107
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (GLI1 protein, human)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Ligands)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (SMO protein, human)
RN  - 0 (Smoothened Receptor)
RN  - 0 (Transcription Factors)
RN  - 0 (Zinc Finger Protein GLI1)
SB  - IM
MH  - Animals
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - Drug Discovery
MH  - Drug Resistance, Neoplasm/genetics
MH  - Hedgehog Proteins/*antagonists & inhibitors/genetics/*metabolism
MH  - Humans
MH  - Ligands
MH  - Models, Biological
MH  - Molecular Targeted Therapy
MH  - Mutation
MH  - Neoplasms/*drug therapy/genetics/*metabolism
MH  - Neoplastic Stem Cells/drug effects/metabolism
MH  - Receptors, G-Protein-Coupled/antagonists & inhibitors/genetics/metabolism
MH  - Signal Transduction
MH  - Smoothened Receptor
MH  - Transcription Factors/metabolism
MH  - Translational Research, Biomedical
MH  - Zinc Finger Protein GLI1
EDAT- 2013/11/10 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/11/09 06:00
PHST- 2013/05/07 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - nm.3389 [pii]
AID - 10.1038/nm.3389 [doi]
PST - ppublish
SO  - Nat Med. 2013 Nov;19(11):1410-22. doi: 10.1038/nm.3389. Epub 2013 Nov 7.