PMID- 24308963
OWN - NLM
STAT- MEDLINE
DCOM- 20141001
LR  - 20220409
IS  - 1873-3913 (Electronic)
IS  - 0898-6568 (Linking)
VI  - 26
IP  - 3
DP  - 2014 Mar
TI  - Wnt signaling in adult intestinal stem cells and cancer.
PG  - 570-9
LID - S0898-6568(13)00363-X [pii]
LID - 10.1016/j.cellsig.2013.11.032 [doi]
AB  - Signaling initiated by secreted glycoproteins of the Wnt family regulates many 
      aspects of embryonic development and it is involved in homeostasis of adult 
      tissues. In the gastrointestinal (GI) tract the Wnt pathway maintains the 
      self-renewal capacity of epithelial stem cells. The stem cell attributes are 
      conferred by mutual interactions of the stem cell with its local 
      microenvironment, the stem cell niche. The niche ensures that the threshold of 
      Wnt signaling in the stem cell is kept in physiological range. In addition, the 
      Wnt pathway involves various feedback loops that balance the opposing processes 
      of cell proliferation and differentiation. Today, we have compelling evidence 
      that mutations causing aberrant activation of the Wnt pathway promote expansion 
      of undifferentiated progenitors and lead to cancer. The review summarizes recent 
      advances in characterization of adult epithelial stem cells in the gut. We mainly 
      focus on discoveries related to molecular mechanisms regulating the output of the 
      Wnt pathway. Moreover, we present novel experimental approaches utilized to 
      investigate the epithelial cell signaling circuitry in vivo and in vitro. Pivotal 
      aspects of tissue homeostasis are often deduced from studies of tumor cells; 
      therefore, we also discuss some latest results gleaned from the deep genome 
      sequencing studies of human carcinomas of the colon and rectum.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Krausova, Michaela
AU  - Krausova M
AD  - Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 
      Videnska 1083, 142 20 Prague 4, Czech Republic.
FAU - Korinek, Vladimir
AU  - Korinek V
AD  - Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 
      Videnska 1083, 142 20 Prague 4, Czech Republic. Electronic address: 
      korinek@img.cas.cz.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131202
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Wnt Proteins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Adult Stem Cells/*metabolism
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Transformation, Neoplastic/*genetics/pathology
MH  - Epithelial Cells/cytology
MH  - Gastrointestinal Neoplasms/*genetics/pathology
MH  - Humans
MH  - Intestinal Mucosa/cytology
MH  - Intestines/pathology
MH  - Stem Cell Niche
MH  - Wnt Proteins/genetics/*metabolism
MH  - Wnt Signaling Pathway/*genetics
MH  - beta Catenin/metabolism
OTO - NOTNLM
OT  - APC
OT  - Adenomatous Polyposis Coli
OT  - Axin
OT  - BMP
OT  - CBC
OT  - CRC
OT  - CSCs
OT  - Colorectal cancer
OT  - Dickkopf
OT  - Dkk
OT  - FAP
OT  - Familial Adenomatous Polyposis
OT  - GI
OT  - GSK3
OT  - Gut
OT  - ISCs
OT  - LEF/TCF
OT  - LGR
OT  - LRCs
OT  - LRP
OT  - MSI
OT  - MSS
OT  - Mouse models
OT  - Organoids
OT  - R-spondin
OT  - Rnf43
OT  - Rspo
OT  - TAZ
OT  - Tumor
OT  - YAP
OT  - Yes-associated protein
OT  - Znfr3
OT  - axis inhibition protein
OT  - beta-transducin repeat containing protein
OT  - bone morphogenic protein
OT  - cancer stem cells
OT  - colorectal carcinoma
OT  - crypt base columnar
OT  - gastrointestinal
OT  - glycogen synthase kinase 3
OT  - intestinal stem cells
OT  - label-retaining cells
OT  - leucine-rich G protein coupled receptor
OT  - low density lipoprotein receptor-related protein
OT  - lymphoid enhancer-binding factor/T-cell factor
OT  - microsatellite instability
OT  - microsatellite-stable
OT  - ring finger 43
OT  - transcriptional co-activator with PDZ-binding motif
OT  - zinc and ring finger 3
OT  - beta-TrCP
EDAT- 2013/12/07 06:00
MHDA- 2014/10/02 06:00
CRDT- 2013/12/07 06:00
PHST- 2013/11/04 00:00 [received]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2014/10/02 06:00 [medline]
AID - S0898-6568(13)00363-X [pii]
AID - 10.1016/j.cellsig.2013.11.032 [doi]
PST - ppublish
SO  - Cell Signal. 2014 Mar;26(3):570-9. doi: 10.1016/j.cellsig.2013.11.032. Epub 2013 
      Dec 2.