PMID- 24326621
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20220318
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Jan
TI  - Adult intestinal stem cells: critical drivers of epithelial homeostasis and 
      regeneration.
PG  - 19-33
LID - 10.1038/nrm3721 [doi]
AB  - Small populations of adult stem cells are responsible for the remarkable ability 
      of the epithelial lining of the intestine to be efficiently renewed and repaired 
      throughout life. The recent discovery of specific markers for these stem cells, 
      together with the development of new technologies to track endogenous stem cell 
      activity in vivo and to exploit their ability to generate new epithelia ex vivo, 
      has greatly improved our understanding of stem cell-driven homeostasis, 
      regeneration and cancer in the intestine. These exciting new insights into the 
      biology of intestinal stem cells have the potential to accelerate the development 
      of stem cell-based therapies and ameliorate cancer treatments.
FAU - Barker, Nick
AU  - Barker N
AD  - A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 
      Singapore. MRC Centre for Regenerative Medicine, The University of Edinburgh, 5 
      Little France Drive, Edinburgh EH16 4UU, UK. Department of Biochemistry, Yong Loo 
      Lin School of Medicine, National University of Singapore, 117596 Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131211
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
SB  - IM
MH  - Adult Stem Cells/*physiology
MH  - Animals
MH  - Cell Lineage
MH  - Epithelial Cells/*physiology
MH  - Homeostasis
MH  - Humans
MH  - Intestinal Mucosa/*cytology/physiology
MH  - Models, Biological
MH  - *Regeneration
MH  - Stem Cell Niche
EDAT- 2013/12/12 06:00
MHDA- 2014/02/19 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - nrm3721 [pii]
AID - 10.1038/nrm3721 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2014 Jan;15(1):19-33. doi: 10.1038/nrm3721. Epub 2013 Dec 
      11.