PMID- 24395130
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20240330
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 49
IP  - 3
DP  - 2014 Jun
TI  - Phagocytosis of microglia in the central nervous system diseases.
PG  - 1422-34
LID - 10.1007/s12035-013-8620-6 [doi]
AB  - Microglia, the resident macrophages of the central nervous system, rapidly 
      activate in nearly all kinds of neurological diseases. These activated microglia 
      become highly motile, secreting inflammatory cytokines, migrating to the lesion 
      area, and phagocytosing cell debris or damaged neurons. During the past decades, 
      the secretory property and chemotaxis of microglia have been well-studied, while 
      relatively less attention has been paid to microglial phagocytosis. So far there 
      is no obvious concordance with whether it is beneficial or detrimental in tissue 
      repair. This review focuses on phagocytic phenotype of microglia in neurological 
      diseases such as Alzheimer's disease, multiple sclerosis, Parkinson's disease, 
      traumatic brain injury, ischemic and other brain diseases. Microglial 
      morphological characteristics, involved receptors and signaling pathways, 
      distribution variation along with time and space changes, and environmental 
      factors that affecting phagocytic function in each disease are reviewed. 
      Moreover, a comparison of contributions between macrophages from peripheral 
      circulation and the resident microglia to these pathogenic processes will also be 
      discussed.
FAU - Fu, Ruying
AU  - Fu R
AD  - Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Number 107, Yan Jiang Xi Road, Guangzhou, 510120, Guangdong Province, China.
FAU - Shen, Qingyu
AU  - Shen Q
FAU - Xu, Pengfei
AU  - Xu P
FAU - Luo, Jin Jun
AU  - Luo JJ
FAU - Tang, Yamei
AU  - Tang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140107
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
SB  - IM
MH  - Animals
MH  - Central Nervous System Diseases/*metabolism/pathology
MH  - Humans
MH  - Microglia/*metabolism/pathology
MH  - Phagocytosis/*physiology
MH  - Signal Transduction/*physiology
PMC - PMC4012154
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2014/01/08 06:00
MHDA- 2015/01/27 06:00
PMCR- 2014/01/07
CRDT- 2014/01/08 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2013/12/15 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
PHST- 2014/01/07 00:00 [pmc-release]
AID - 8620 [pii]
AID - 10.1007/s12035-013-8620-6 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2014 Jun;49(3):1422-34. doi: 10.1007/s12035-013-8620-6. Epub 2014 
      Jan 7.