PMID- 24517450
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20220317
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 8
IP  - 3
DP  - 2014 Mar 25
TI  - Protein corona fingerprinting predicts the cellular interaction of gold and 
      silver nanoparticles.
PG  - 2439-55
LID - 10.1021/nn406018q [doi]
AB  - Using quantitative models to predict the biological interactions of nanoparticles 
      will accelerate the translation of nanotechnology. Here, we characterized the 
      serum protein corona 'fingerprint' formed around a library of 105 
      surface-modified gold nanoparticles. Applying a bioinformatics-inspired approach, 
      we developed a multivariate model that uses the protein corona fingerprint to 
      predict cell association 50% more accurately than a model that uses parameters 
      describing nanoparticle size, aggregation state, and surface charge. Our model 
      implicates a set of hyaluronan-binding proteins as mediators of nanoparticle-cell 
      interactions. This study establishes a framework for developing a comprehensive 
      database of protein corona fingerprints and biological responses for multiple 
      nanoparticle types. Such a database can be used to develop quantitative 
      relationships that predict the biological responses to nanoparticles and will aid 
      in uncovering the fundamental mechanisms of nano-bio interactions.
FAU - Walkey, Carl D
AU  - Walkey CD
AD  - Institute of Biomaterials and Biomedical Engineering, double daggerBanting and Best 
      Department of Medical Research,  section signDonnelly Centre for Cellular and Biomolecular 
      Research,  perpendicularDepartment of Chemical Engineering,  parallelDepartment of Chemistry, 
      #Department of Materials Science and Engineering, University of Toronto , 
      Toronto, Ontario, Canada M5S 3G9.
FAU - Olsen, Jonathan B
AU  - Olsen JB
FAU - Song, Fayi
AU  - Song F
FAU - Liu, Rong
AU  - Liu R
FAU - Guo, Hongbo
AU  - Guo H
FAU - Olsen, D Wesley H
AU  - Olsen DW
FAU - Cohen, Yoram
AU  - Cohen Y
FAU - Emili, Andrew
AU  - Emili A
FAU - Chan, Warren C W
AU  - Chan WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140225
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Blood Proteins)
RN  - 3M4G523W1G (Silver)
RN  - 7440-57-5 (Gold)
SB  - IM
CIN - ACS Nano. 2015 Jun 23;9(6):5634-5. PMID: 26100222
MH  - Blood Proteins/*metabolism
MH  - Cell Line
MH  - Gold/*chemistry/*metabolism
MH  - Humans
MH  - *Metal Nanoparticles
MH  - Nanotechnology
MH  - Particle Size
MH  - Protein Binding
MH  - Silver/*chemistry/*metabolism
EDAT- 2014/02/13 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/02/13 06:00
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - 10.1021/nn406018q [doi]
PST - ppublish
SO  - ACS Nano. 2014 Mar 25;8(3):2439-55. doi: 10.1021/nn406018q. Epub 2014 Feb 25.