PMID- 24518612
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140212
LR  - 20211021
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 6
IP  - 1
DP  - 2014 Feb 10
TI  - STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications.
PG  - 376-95
LID - 10.3390/cancers6010376 [doi]
AB  - Signal transducer and activator of transcription 3 (STAT3) is a potent regulator 
      of gliomagenesis through its induction of angiogenesis, host immunosuppression, 
      and tumor invasion. Gain of function mutations result in constitutive activation 
      of STAT3 in glioma cells, making STAT3 an attractive target for inhibition in 
      cancer therapy. Nevertheless, some studies show that STAT3 also participates in 
      terminal differentiation and apoptosis of various cell lines and in glioma with 
      phosphatase and tensin homolog (PTEN)-deficient genetic backgrounds. In light of 
      these findings, the utility of STAT3 as a prognostic indicator and as a target of 
      drug therapies will be contingent on a more nuanced understanding of its pro- and 
      anti-tumorigenic effects.
FAU - Kim, Jennifer E
AU  - Kim JE
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 
      N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. jkim256@jhmi.edu.
FAU - Patel, Mira
AU  - Patel M
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 
      N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. 
      mpatel50@jhmi.edu.
FAU - Ruzevick, Jacob
AU  - Ruzevick J
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 
      N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. 
      jruzevick@jhmi.edu.
FAU - Jackson, Christopher M
AU  - Jackson CM
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 
      N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. 
      cjacks53@jhmi.edu.
FAU - Lim, Michael
AU  - Lim M
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 
      N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. mlim3@jhmi.edu.
LA  - eng
PT  - Journal Article
DEP - 20140210
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC3980601
EDAT- 2014/02/13 06:00
MHDA- 2014/02/13 06:01
PMCR- 2014/02/10
CRDT- 2014/02/13 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/01/19 00:00 [revised]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/02/13 06:01 [medline]
PHST- 2014/02/10 00:00 [pmc-release]
AID - cancers6010376 [pii]
AID - cancers-06-00376 [pii]
AID - 10.3390/cancers6010376 [doi]
PST - epublish
SO  - Cancers (Basel). 2014 Feb 10;6(1):376-95. doi: 10.3390/cancers6010376.