PMID- 24550109
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20211021
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 141
IP  - 5
DP  - 2014 Mar
TI  - Transcription factor expression uniquely identifies most postembryonic neuronal 
      lineages in the Drosophila thoracic central nervous system.
PG  - 1011-21
LID - 10.1242/dev.102178 [doi]
AB  - Most neurons of the adult Drosophila ventral nerve cord arise from a burst of 
      neurogenesis during the third larval instar stage. Most of this growth occurs in 
      thoracic neuromeres, which contain 25 individually identifiable postembryonic 
      neuronal lineages. Initially, each lineage consists of two hemilineages--'A' 
      (Notch(On)) and 'B' (Notch(Off))--that exhibit distinct axonal trajectories or 
      fates. No reliable method presently exists to identify these lineages or 
      hemilineages unambiguously other than labor-intensive lineage-tracing methods. By 
      combining mosaic analysis with a repressible cell marker (MARCM) analysis with 
      gene expression studies, we constructed a gene expression map that enables the 
      rapid, unambiguous identification of 23 of the 25 postembryonic lineages based on 
      the expression of 15 transcription factors. Pilot genetic studies reveal that 
      these transcription factors regulate the specification and differentiation of 
      postembryonic neurons: for example, Nkx6 is necessary and sufficient to direct 
      axonal pathway selection in lineage 3. The gene expression map thus provides a 
      descriptive foundation for the genetic and molecular dissection of adult-specific 
      neurogenesis and identifies many transcription factors that are likely to 
      regulate the development and differentiation of discrete subsets of postembryonic 
      neurons.
FAU - Lacin, Haluk
AU  - Lacin H
AD  - Department of Genetics, Washington University School of Medicine, 4566 Scott 
      Avenue, St Louis, MO 63110, USA.
FAU - Zhu, Yi
AU  - Zhu Y
FAU - Wilson, Beth A
AU  - Wilson BA
FAU - Skeath, James B
AU  - Skeath JB
LA  - eng
GR  - R01 NS036570/NS/NINDS NIH HHS/United States
GR  - NS036570/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Drosophila Proteins)
RN  - 0 (HGTX protein, Drosophila)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Lim3 protein, Drosophila)
RN  - 0 (Transcription Factors)
RN  - 0 (exex protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Central Nervous System/cytology/*metabolism
MH  - Drosophila
MH  - Drosophila Proteins/genetics/*metabolism
MH  - Homeodomain Proteins/genetics/metabolism
MH  - LIM-Homeodomain Proteins/genetics/metabolism
MH  - Neurogenesis/genetics/physiology
MH  - Neurons/cytology/metabolism
MH  - Transcription Factors/genetics/*metabolism
PMC - PMC3929408
OTO - NOTNLM
OT  - Adult neurogenesis
OT  - Drosophila
OT  - Gene expression map
OT  - Hb9
EDAT- 2014/02/20 06:00
MHDA- 2014/05/03 06:00
PMCR- 2015/03/01
CRDT- 2014/02/20 06:00
PHST- 2014/02/20 06:00 [entrez]
PHST- 2014/02/20 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 141/5/1011 [pii]
AID - 10.1242/dev.102178 [doi]
PST - ppublish
SO  - Development. 2014 Mar;141(5):1011-21. doi: 10.1242/dev.102178.