PMID- 24629344
OWN - NLM
STAT- MEDLINE
DCOM- 20141103
LR  - 20240109
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Print)
IS  - 1931-3128 (Linking)
VI  - 15
IP  - 3
DP  - 2014 Mar 12
TI  - The treatment-naive microbiome in new-onset Crohn's disease.
PG  - 382-392
LID - 10.1016/j.chom.2014.02.005 [doi]
AB  - Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are 
      genetically linked to host pathways that implicate an underlying role for 
      aberrant immune responses to intestinal microbiota. However, patterns of gut 
      microbiome dysbiosis in IBD patients are inconsistent among published studies. 
      Using samples from multiple gastrointestinal locations collected prior to 
      treatment in new-onset cases, we studied the microbiome in the largest pediatric 
      CD cohort to date. An axis defined by an increased abundance in bacteria which 
      include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and 
      Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, 
      and Clostridiales, correlates strongly with disease status. Microbiome comparison 
      between CD patients with and without antibiotic exposure indicates that 
      antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing 
      the microbial signatures between the ileum, the rectum, and fecal samples 
      indicates that at this early stage of disease, assessing the rectal 
      mucosal-associated microbiome offers unique potential for convenient and early 
      diagnosis of CD.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Gevers, Dirk
AU  - Gevers D
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
FAU - Kugathasan, Subra
AU  - Kugathasan S
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 
      Emory University, Atlanta, GA 30322, USA.
FAU - Denson, Lee A
AU  - Denson LA
AD  - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's 
      Hospital Medical Center, Cincinnati, OH 45229, USA.
FAU - Vazquez-Baeza, Yoshiki
AU  - Vazquez-Baeza Y
AD  - Department of Computer Science, University of Colorado, Boulder, Colorado 80309, 
      USA.
FAU - Van Treuren, Will
AU  - Van Treuren W
AD  - BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
FAU - Ren, Boyu
AU  - Ren B
AD  - Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 
      USA.
FAU - Schwager, Emma
AU  - Schwager E
AD  - Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 
      USA.
FAU - Knights, Dan
AU  - Knights D
AD  - Department of Computer Science and Engineering, University of Minnesota, 
      Minneapolis, MN 55108, USA.
AD  - BioTechnology Institute, University of Minnesota, St. Paul, MN 55108, USA.
FAU - Song, Se Jin
AU  - Song SJ
AD  - BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
FAU - Yassour, Moran
AU  - Yassour M
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
FAU - Morgan, Xochitl C
AU  - Morgan XC
AD  - Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 
      USA.
FAU - Kostic, Aleksandar D
AU  - Kostic AD
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
FAU - Luo, Chengwei
AU  - Luo C
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
FAU - Gonzalez, Antonio
AU  - Gonzalez A
AD  - BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
FAU - McDonald, Daniel
AU  - McDonald D
AD  - BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
FAU - Haberman, Yael
AU  - Haberman Y
AD  - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's 
      Hospital Medical Center, Cincinnati, OH 45229, USA.
FAU - Walters, Thomas
AU  - Walters T
AD  - Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick 
      Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
FAU - Baker, Susan
AU  - Baker S
AD  - Children's Hospital of Buffalo, Buffalo, NY 14222, USA.
FAU - Rosh, Joel
AU  - Rosh J
AD  - Goryeb Children's Hospital, Morristown, NJ 07960, USA.
FAU - Stephens, Michael
AU  - Stephens M
AD  - Mayo Clinic, Rochester, MN 55902, USA.
FAU - Heyman, Melvin
AU  - Heyman M
AD  - University of California, San Francisco, CA 94143, USA.
FAU - Markowitz, James
AU  - Markowitz J
AD  - North Shore Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
FAU - Baldassano, Robert
AU  - Baldassano R
AD  - Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
FAU - Griffiths, Anne
AU  - Griffiths A
AD  - Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
FAU - Sylvester, Francisco
AU  - Sylvester F
AD  - Connecticut Children's Medical Center, Hartford, CT 06106, USA.
FAU - Mack, David
AU  - Mack D
AD  - Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1 Canada.
FAU - Kim, Sandra
AU  - Kim S
AD  - Nationwide Children's Hospital, Columbus, OH 43228, USA.
FAU - Crandall, Wallace
AU  - Crandall W
AD  - Nationwide Children's Hospital, Columbus, OH 43228, USA.
FAU - Hyams, Jeffrey
AU  - Hyams J
AD  - Connecticut Children's Medical Center, Hartford, CT 06106, USA.
FAU - Huttenhower, Curtis
AU  - Huttenhower C
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
AD  - Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 
      USA.
FAU - Knight, Rob
AU  - Knight R
AD  - BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
AD  - Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 
      80309, USA.
AD  - Howard Hughes Medical Institute, Boulder, CO 80309, USA.
FAU - Xavier, Ramnik J
AU  - Xavier RJ
AD  - Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
AD  - Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, 
      Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
AD  - Center for Computational and Integrative Biology, Massachusetts General Hospital 
      and Harvard Medical School, Boston, MA 02114, USA.
LA  - eng
GR  - P30 DK043351/DK/NIDDK NIH HHS/United States
GR  - R01 DK092405/DK/NIDDK NIH HHS/United States
GR  - R01DK092405/DK/NIDDK NIH HHS/United States
GR  - T32 GM074897/GM/NIGMS NIH HHS/United States
GR  - U54 DE023798/DE/NIDCR NIH HHS/United States
GR  - R01 HG005969/HG/NHGRI NIH HHS/United States
GR  - U54 DK102557/DK/NIDDK NIH HHS/United States
GR  - R35 CA197449/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
SB  - IM
CIN - Nat Rev Microbiol. 2014 May;12(5):312. PMID: 24638106
CIN - Nat Rev Gastroenterol Hepatol. 2014 May;11(5):268. PMID: 24662277
CIN - Gastroenterology. 2014 Oct;147(4):932-4. PMID: 25152198
MH  - Adolescent
MH  - Bacteria/*classification/isolation & purification
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Crohn Disease/*complications/*microbiology
MH  - *Dysbiosis
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - Metagenome
MH  - *Microbiota
PMC - PMC4059512
MID - NIHMS569508
EDAT- 2014/03/19 06:00
MHDA- 2014/11/05 06:00
PMCR- 2015/03/12
CRDT- 2014/03/18 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2014/01/31 00:00 [revised]
PHST- 2014/02/12 00:00 [accepted]
PHST- 2014/03/18 06:00 [entrez]
PHST- 2014/03/19 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
PHST- 2015/03/12 00:00 [pmc-release]
AID - 10.1016/j.chom.2014.02.005 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2014 Mar 12;15(3):382-392. doi: 10.1016/j.chom.2014.02.005.