PMID- 24657538
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20240210
IS  - 1879-0380 (Electronic)
IS  - 0959-437X (Linking)
VI  - 24
DP  - 2014 Feb
TI  - The evolution of the unstable cancer genome.
PG  - 61-7
LID - S0959-437X(13)00160-3 [pii]
LID - 10.1016/j.gde.2013.11.011 [doi]
AB  - Cancer next-generation sequencing and genomics studies published over the last 
      five years have provided unprecedented insights into the forces shaping cancer 
      genome evolution. In particular, these studies have revealed a high level of 
      heterogeneity not only between different tumours, but also within individual 
      tumours; the 'cancer genome' may evolve along several independent trajectories 
      within a single tumour. There is an increasing appreciation of the importance of 
      intratumour genetic heterogeneity in determining disease progression and clinical 
      outcome in cancer medicine, and thus an increasing awareness of the need to 
      understand the processes that both generate genetic diversity and shape genome 
      evolution in human tumours.
CI  - Copyright (c) 2013. Published by Elsevier Ltd.
FAU - Burrell, Rebecca A
AU  - Burrell RA
AD  - Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research 
      Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
FAU - Swanton, Charles
AU  - Swanton C
AD  - Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research 
      Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK; UCL Cancer Institute, 
      Paul O'Gorman Building University College London, 72 Huntley Street, London WC1E 
      6DD, UK. Electronic address: charles.swanton@cancer.org.uk.
LA  - eng
GR  - 19310/CRUK_/Cancer Research UK/United Kingdom
GR  - G0701935/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20131231
PL  - England
TA  - Curr Opin Genet Dev
JT  - Current opinion in genetics & development
JID - 9111375
SB  - IM
MH  - Animals
MH  - Genetic Predisposition to Disease
MH  - *Genome, Human
MH  - Genomics
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Recurrence
EDAT- 2014/03/25 06:00
MHDA- 2014/11/02 06:00
CRDT- 2014/03/25 06:00
PHST- 2013/09/27 00:00 [received]
PHST- 2013/11/17 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
AID - S0959-437X(13)00160-3 [pii]
AID - 10.1016/j.gde.2013.11.011 [doi]
PST - ppublish
SO  - Curr Opin Genet Dev. 2014 Feb;24:61-7. doi: 10.1016/j.gde.2013.11.011. Epub 2013 
      Dec 31.