PMID- 2472670
OWN - NLM
STAT- MEDLINE
DCOM- 19890801
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 244
IP  - 4912
DP  - 1989 Jun 30
TI  - Adenylyl cyclase amino acid sequence: possible channel- or transporter-like 
      structure.
PG  - 1558-64
AB  - Complementary DNA's that encode an adenylyl cyclase were isolated from a bovine 
      brain library. Most of the deduced amino acid sequence of 1134 residues is 
      divisible into two alternating sets of hydrophobic and hydrophilic domains. Each 
      of the two large hydrophobic domains appears to contain six transmembrane spans. 
      Each of the two large hydrophilic domains contains a sequence that is homologous 
      to a single cytoplasmic domain of several guanylyl cyclases; these sequences may 
      represent nucleotide binding sites. An unexpected topographical resemblance 
      between adenylyl cyclase and various plasma membrane channels and transporters 
      was observed. This structural complexity suggests possible, unappreciated 
      functions for this important enzyme.
FAU - Krupinski, J
AU  - Krupinski J
AD  - Department of Pharmacology, University of Texas Southwestern Medical Center, 
      Dallas 75235.
FAU - Coussen, F
AU  - Coussen F
FAU - Bakalyar, H A
AU  - Bakalyar HA
FAU - Tang, W J
AU  - Tang WJ
FAU - Feinstein, P G
AU  - Feinstein PG
FAU - Orth, K
AU  - Orth K
FAU - Slaughter, C
AU  - Slaughter C
FAU - Reed, R R
AU  - Reed RR
FAU - Gilman, A G
AU  - Gilman AG
LA  - eng
SI  - GENBANK/M25579
GR  - CA16519/CA/NCI NIH HHS/United States
GR  - GM12230/GM/NIGMS NIH HHS/United States
GR  - GM34497/GM/NIGMS NIH HHS/United States
GR  - etc.
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Carrier Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
SB  - IM
MH  - *Adenylyl Cyclases/genetics/isolation & purification
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/enzymology
MH  - *Carrier Proteins
MH  - Cattle
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Electrophoresis, Polyacrylamide Gel
MH  - *Ion Channels
MH  - Membrane Proteins
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Protein Conformation
MH  - Transfection
EDAT- 1989/06/30 00:00
MHDA- 1989/06/30 00:01
CRDT- 1989/06/30 00:00
PHST- 1989/06/30 00:00 [pubmed]
PHST- 1989/06/30 00:01 [medline]
PHST- 1989/06/30 00:00 [entrez]
AID - 10.1126/science.2472670 [doi]
PST - ppublish
SO  - Science. 1989 Jun 30;244(4912):1558-64. doi: 10.1126/science.2472670.