PMID- 24920463
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20211021
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 14
IP  - 7
DP  - 2014 Jul
TI  - Stem cell dynamics in homeostasis and cancer of the intestine.
PG  - 468-80
LID - 10.1038/nrc3744 [doi]
AB  - Intestinal stem cells (ISCs) and colorectal cancer (CRC) biology are tightly 
      linked in many aspects. It is generally thought that ISCs are the cells of origin 
      for a large proportion of CRCs and crucial ISC-associated signalling pathways are 
      often affected in CRCs. Moreover, CRCs are thought to retain a cellular hierarchy 
      that is reminiscent of the intestinal epithelium. Recent studies offer 
      quantitative insights into the dynamics of ISC behaviour that govern homeostasis 
      and thereby provide the necessary baseline parameters to begin to apply these 
      analyses during the various stages of tumour development.
FAU - Vermeulen, Louis
AU  - Vermeulen L
AD  - 1] Laboratory for Experimental Oncology and Radiobiology, Center for Experimental 
      Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, 
      The Netherlands. [2] Cancer Research UK - Cambridge Institute, University of 
      Cambridge, Robinson Way, CB2 0RE, Cambridge, UK.
FAU - Snippert, Hugo J
AU  - Snippert HJ
AD  - Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular 
      Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG 
      Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140612
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
SB  - IM
MH  - Animals
MH  - Colorectal Neoplasms/metabolism/pathology
MH  - Homeostasis
MH  - Humans
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/*cytology
MH  - Stem Cells/*cytology/metabolism
EDAT- 2014/06/13 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/06/13 06:00
PHST- 2014/06/13 06:00 [entrez]
PHST- 2014/06/13 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - nrc3744 [pii]
AID - 10.1038/nrc3744 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2014 Jul;14(7):468-80. doi: 10.1038/nrc3744. Epub 2014 Jun 12.