PMID- 24946761
OWN - NLM
STAT- MEDLINE
DCOM- 20140807
LR  - 20240324
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Print)
IS  - 1471-003X (Linking)
VI  - 15
IP  - 7
DP  - 2014 Jul
TI  - A neurocentric perspective on glioma invasion.
PG  - 455-65
LID - 10.1038/nrn3765 [doi]
AB  - Malignant gliomas are devastating tumours that frequently kill patients within 1 
      year of diagnosis. The major obstacle to a cure is diffuse invasion, which 
      enables tumours to escape complete surgical resection and chemo- and radiation 
      therapy. Gliomas use the same tortuous extracellular routes of migration that are 
      travelled by immature neurons and stem cells, frequently using blood vessels as 
      guides. They repurpose ion channels to dynamically adjust their cell volume to 
      accommodate to narrow spaces and breach the blood-brain barrier through 
      disruption of astrocytic endfeet, which envelop blood vessels. The unique biology 
      of glioma invasion provides hitherto unexplored brain-specific therapeutic 
      targets for this devastating disease.
FAU - Cuddapah, Vishnu Anand
AU  - Cuddapah VA
AD  - Department of Neurobiology, Center for Glial Biology in Medicine, University of 
      Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 
      35294, USA.
FAU - Robel, Stefanie
AU  - Robel S
AD  - Department of Neurobiology, Center for Glial Biology in Medicine, University of 
      Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 
      35294, USA.
FAU - Watkins, Stacey
AU  - Watkins S
AD  - Department of Neurobiology, Center for Glial Biology in Medicine, University of 
      Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 
      35294, USA.
FAU - Sontheimer, Harald
AU  - Sontheimer H
AD  - Department of Neurobiology, Center for Glial Biology in Medicine, University of 
      Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 
      35294, USA.
LA  - eng
GR  - R01 NS082851/NS/NINDS NIH HHS/United States
GR  - R01 NS031234/NS/NINDS NIH HHS/United States
GR  - F31 NS074597/NS/NINDS NIH HHS/United States
GR  - 5R01NS031234/NS/NINDS NIH HHS/United States
GR  - F31NS074597/NS/NINDS NIH HHS/United States
GR  - 5R01‑NS052634/NS/NINDS NIH HHS/United States
GR  - R01 NS052634/NS/NINDS NIH HHS/United States
GR  - R01 NS036692/NS/NINDS NIH HHS/United States
GR  - 2R01‑NS036692/NS/NINDS NIH HHS/United States
GR  - 1R01‑NS082851/NS/NINDS NIH HHS/United States
GR  - F31 NS073181/NS/NINDS NIH HHS/United States
GR  - F31NS073181/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*pathology
MH  - Brain Neoplasms/genetics/*pathology
MH  - Cell Movement/physiology
MH  - Glioma/genetics/*pathology
MH  - Humans
MH  - Neoplasm Invasiveness/genetics/pathology
PMC - PMC5304245
MID - NIHMS841517
EDAT- 2014/06/21 06:00
MHDA- 2014/08/08 06:00
PMCR- 2017/02/13
CRDT- 2014/06/21 06:00
PHST- 2014/06/21 06:00 [entrez]
PHST- 2014/06/21 06:00 [pubmed]
PHST- 2014/08/08 06:00 [medline]
PHST- 2017/02/13 00:00 [pmc-release]
AID - nrn3765 [pii]
AID - 10.1038/nrn3765 [doi]
PST - ppublish
SO  - Nat Rev Neurosci. 2014 Jul;15(7):455-65. doi: 10.1038/nrn3765.