PMID- 24995985
OWN - NLM
STAT- MEDLINE
DCOM- 20140918
LR  - 20220129
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 158
IP  - 1
DP  - 2014 Jul 3
TI  - Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.
PG  - 143-156
LID - 10.1016/j.cell.2014.05.035 [doi]
AB  - Mechanical forces have been proposed to modulate organ growth, but a molecular 
      mechanism that links them to growth regulation in vivo has been lacking. We 
      report that increasing tension within the cytoskeleton increases Drosophila wing 
      growth, whereas decreasing cytoskeletal tension decreases wing growth. These 
      changes in growth can be accounted for by changes in the activity of Yorkie, a 
      transcription factor regulated by the Hippo pathway. The influence of myosin 
      activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative 
      regulator of Warts within the Hippo pathway. We further show that Jub associates 
      with alpha-catenin and that its localization to adherens junctions and association 
      with alpha-catenin are promoted by cytoskeletal tension. Jub recruits Warts to 
      junctions in a tension-dependent manner. Our observations delineate a mechanism 
      that links cytoskeletal tension to regulation of Hippo pathway activity, 
      providing a molecular understanding of how mechanical forces can modulate organ 
      growth.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Rauskolb, Cordelia
AU  - Rauskolb C
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway 
      NJ 08854 USA.
FAU - Sun, Shuguo
AU  - Sun S
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway 
      NJ 08854 USA.
FAU - Sun, Gongping
AU  - Sun G
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway 
      NJ 08854 USA.
FAU - Pan, Yuanwang
AU  - Pan Y
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway 
      NJ 08854 USA.
FAU - Irvine, Kenneth D
AU  - Irvine KD
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway 
      NJ 08854 USA.
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 GM078620/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - 0 (jub protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
CIN - Nat Rev Mol Cell Biol. 2014 Aug;15(8):501. PMID: 25053357
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Cytoskeleton/*metabolism
MH  - Drosophila/*growth & development/metabolism
MH  - Drosophila Proteins/*metabolism
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - LIM Domain Proteins/*metabolism
MH  - Nuclear Proteins/metabolism
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - *Signal Transduction
MH  - Trans-Activators/metabolism
MH  - Wings, Animal/*growth & development/metabolism
MH  - YAP-Signaling Proteins
PMC - PMC4082802
MID - NIHMS604590
EDAT- 2014/07/06 06:00
MHDA- 2014/09/19 06:00
PMCR- 2015/07/03
CRDT- 2014/07/05 06:00
PHST- 2013/11/04 00:00 [received]
PHST- 2014/02/18 00:00 [revised]
PHST- 2014/05/08 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/09/19 06:00 [medline]
PHST- 2015/07/03 00:00 [pmc-release]
AID - S0092-8674(14)00722-3 [pii]
AID - 10.1016/j.cell.2014.05.035 [doi]
PST - ppublish
SO  - Cell. 2014 Jul 3;158(1):143-156. doi: 10.1016/j.cell.2014.05.035.