PMID- 25079552 OWN - NLM STAT- MEDLINE DCOM- 20140916 LR - 20220413 IS - 1476-4687 (Electronic) IS - 0028-0836 (Print) IS - 0028-0836 (Linking) VI - 511 IP - 7511 DP - 2014 Jul 31 TI - Comprehensive molecular profiling of lung adenocarcinoma. PG - 543-50 LID - 10.1038/nature13385 [doi] AB - Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. CN - Cancer Genome Atlas Research Network LA - eng GR - U24 CA143882/CA/NCI NIH HHS/United States GR - U24 CA143866/CA/NCI NIH HHS/United States GR - U24 CA126551/CA/NCI NIH HHS/United States GR - HHMI/Howard Hughes Medical Institute/United States GR - U24 CA143843/CA/NCI NIH HHS/United States GR - U24 CA126543/CA/NCI NIH HHS/United States GR - U54 HG003079/HG/NHGRI NIH HHS/United States GR - U24 CA143883/CA/NCI NIH HHS/United States GR - U24 CA143867/CA/NCI NIH HHS/United States GR - U24 CA126546/CA/NCI NIH HHS/United States GR - UL1 TR000005/TR/NCATS NIH HHS/United States GR - P30 CA016672/CA/NCI NIH HHS/United States GR - U54 HG003067/HG/NHGRI NIH HHS/United States GR - U24 CA143835/CA/NCI NIH HHS/United States GR - K08 CA137153/CA/NCI NIH HHS/United States GR - P30 CA006973/CA/NCI NIH HHS/United States GR - U24 CA143845/CA/NCI NIH HHS/United States GR - U24 CA143799/CA/NCI NIH HHS/United States GR - T32 GM007753/GM/NIGMS NIH HHS/United States GR - U54 HG003273/HG/NHGRI NIH HHS/United States GR - P30 CA008748/CA/NCI NIH HHS/United States GR - U24 CA144025/CA/NCI NIH HHS/United States GR - U24 CA126554/CA/NCI NIH HHS/United States GR - U24 CA180951/CA/NCI NIH HHS/United States GR - U24 CA143840/CA/NCI NIH HHS/United States GR - U24 CA126561/CA/NCI NIH HHS/United States GR - U24 CA137153/CA/NCI NIH HHS/United States GR - U24 CA143858/CA/NCI NIH HHS/United States GR - P30 CA177558/CA/NCI NIH HHS/United States GR - R01 HG006272/HG/NHGRI NIH HHS/United States GR - U24 CA143848/CA/NCI NIH HHS/United States GR - U24 CA126563/CA/NCI NIH HHS/United States GR - U24 CA126544/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140709 PL - England TA - Nature JT - Nature JID - 0410462 RN - 0 (Cell Cycle Proteins) SB - IM EIN - Nature. 2014 Oct 9;514(7521):262. Rogers, K [corrected to Rodgers, K] EIN - Nature. 2018 Jul;559(7715):E12. doi: 10.1038/s41586-018-0228-6. PMID: 29925941 MH - Adenocarcinoma/*genetics/*pathology MH - Adenocarcinoma of Lung MH - Cell Cycle Proteins/genetics MH - Female MH - Gene Dosage MH - Gene Expression Regulation, Neoplastic MH - *Genomics MH - Humans MH - Lung Neoplasms/*genetics/*pathology MH - Male MH - Molecular Typing MH - Mutation/genetics MH - Oncogenes/genetics MH - Sex Factors MH - Transcriptome/genetics PMC - PMC4231481 MID - NIHMS629713 FIR - Collisson, Eric A IR - Collisson EA FIR - Campbell, Joshua D IR - Campbell JD FIR - Brooks, Angela N IR - Brooks AN FIR - Berger, Alice H IR - Berger AH FIR - Lee, William IR - Lee W FIR - Chmielecki, Juliann IR - Chmielecki J FIR - Beer, David G IR - Beer DG FIR - Cope, Leslie IR - Cope L FIR - Creighton, Chad J IR - Creighton CJ FIR - Danilova, Ludmila IR - Danilova L FIR - Ding, Li IR - Ding L FIR - Getz, Gad IR - Getz G FIR - Hammerman, Peter S IR - Hammerman PS FIR - Hayes, D Neil IR - Hayes DN FIR - Hernandez, Bryan IR - Hernandez B FIR - Herman, James G IR - Herman JG FIR - Heymach, John V IR - Heymach JV FIR - Jurisica, Igor IR - Jurisica I FIR - Kucherlapati, Raju IR - Kucherlapati R FIR - Kwiatkowski, David IR - Kwiatkowski D FIR - Ladanyi, Marc IR - Ladanyi M FIR - Robertson, Gordon IR - Robertson G FIR - Schultz, Nikolaus IR - Schultz N FIR - Shen, Ronglai IR - Shen R FIR - Sinha, Rileen IR - Sinha R FIR - Sougnez, Carrie IR - Sougnez C FIR - Tsao, Ming-Sound IR - Tsao MS FIR - Travis, William D IR - Travis WD FIR - Weinstein, John N IR - Weinstein JN FIR - Wigle, Dennis A IR - Wigle DA FIR - Wilkerson, Matthew D IR - Wilkerson MD FIR - Chu, Andy IR - Chu A FIR - Cherniack, Andrew D IR - Cherniack AD FIR - Hadjipanayis, Angela IR - Hadjipanayis A FIR - Rosenberg, Mara IR - Rosenberg M FIR - Weisenberger, Daniel J IR - Weisenberger DJ FIR - Laird, Peter W IR - Laird PW FIR - Radenbaugh, Amie IR - Radenbaugh A FIR - Ma, Singer IR - Ma S FIR - Stuart, Joshua M IR - Stuart JM FIR - Averett Byers, Lauren IR - Averett Byers L FIR - Baylin, Stephen B IR - Baylin SB FIR - Govindan, Ramaswamy IR - Govindan R FIR - Meyerson, Matthew IR - Meyerson M FIR - Rosenberg, Mara IR - Rosenberg M FIR - Gabriel, Stacey B IR - Gabriel SB FIR - Cibulskis, Kristian IR - Cibulskis K FIR - Sougnez, Carrie IR - Sougnez C FIR - Kim, Jaegil IR - Kim J FIR - Stewart, Chip IR - Stewart C FIR - Lichtenstein, Lee IR - Lichtenstein L FIR - Lander, Eric S IR - Lander ES FIR - Lawrence, Michael S IR - Lawrence MS FIR - Getz IR - Getz FIR - Kandoth, Cyriac IR - Kandoth C FIR - Fulton, Robert IR - Fulton R FIR - Fulton, Lucinda L IR - Fulton LL FIR - McLellan, Michael D IR - McLellan MD FIR - Wilson, Richard K IR - Wilson RK FIR - Ye, Kai IR - Ye K FIR - Fronick, Catrina C IR - Fronick CC FIR - Maher, Christopher A IR - Maher CA FIR - Miller, Christopher A IR - Miller CA FIR - Wendl, Michael C IR - Wendl MC FIR - Cabanski, Christopher IR - Cabanski C FIR - Ding, Li IR - Ding L FIR - Mardis, Elaine IR - Mardis E FIR - Govindan, Ramaswamy IR - Govindan R FIR - Creighton, Chad J IR - Creighton CJ FIR - Wheeler, David IR - Wheeler D FIR - Balasundaram, Miruna IR - Balasundaram M FIR - Butterfield, Yaron S N IR - Butterfield YS FIR - Carlsen, Rebecca IR - Carlsen R FIR - Chu, Andy IR - Chu A FIR - Chuah, Eric IR - Chuah E FIR - Dhalla, Noreen IR - Dhalla N FIR - Guin, Ranabir IR - Guin R FIR - Hirst, Carrie IR - Hirst C FIR - Lee, Darlene IR - Lee D FIR - Li, Haiyan I IR - Li HI FIR - Mayo, Michael IR - Mayo M FIR - Moore, Richard A IR - Moore RA FIR - Mungall, Andrew J IR - Mungall AJ FIR - Schein, Jacqueline E IR - Schein JE FIR - Sipahimalani, Payal IR - Sipahimalani P FIR - Tam, Angela IR - Tam A FIR - Varhol, Richard IR - Varhol R FIR - Robertson, A Gordon IR - Robertson A FIR - Wye, Natasja IR - Wye N FIR - Thiessen, Nina IR - Thiessen N FIR - Holt, Robert A IR - Holt RA FIR - Jones, Steven J M IR - Jones SJ FIR - Marra, Marco A IR - Marra MA FIR - Campbell, Joshua D IR - Campbell JD FIR - Brooks, Angela N IR - Brooks AN FIR - Chmielecki, Juliann IR - Chmielecki J FIR - Imielinski, Marcin IR - Imielinski M FIR - Onofrio, Robert C IR - Onofrio RC FIR - Hodis, Eran IR - Hodis E FIR - Zack, Travis IR - Zack T FIR - Sougnez, Carrie IR - Sougnez C FIR - Helman, Elena IR - Helman E FIR - Sekhar Pedamallu, Chandra IR - Sekhar Pedamallu C FIR - Mesirov, Jill IR - Mesirov J FIR - Cherniack, Andrew D IR - Cherniack AD FIR - Saksena, Gordon IR - Saksena G FIR - Schumacher, Steven E IR - Schumacher SE FIR - Carter, Scott L IR - Carter SL FIR - Hernandez, Bryan IR - Hernandez B FIR - Garraway, Levi IR - Garraway L FIR - Beroukhim, Rameen IR - Beroukhim R FIR - Gabriel, Stacey B IR - Gabriel SB FIR - Getz, Gad IR - Getz G FIR - Meyerson, Matthew IR - Meyerson M FIR - Hadjipanayis, Angela IR - Hadjipanayis A FIR - Lee, Semin IR - Lee S FIR - Mahadeshwar, Harshad S IR - Mahadeshwar HS FIR - Pantazi, Angeliki IR - Pantazi A FIR - Protopopov, Alexei IR - Protopopov A FIR - Ren, Xiaojia IR - Ren X FIR - Seth, Sahil IR - Seth S FIR - Song, Xingzhi IR - Song X FIR - Tang, Jiabin IR - Tang J FIR - Yang, Lixing IR - Yang L FIR - Zhang, Jianhua IR - Zhang J FIR - Chen, Peng-Chieh IR - Chen PC FIR - Parfenov, Michael IR - Parfenov M FIR - Wei Xu, Andrew IR - Wei Xu A FIR - Santoso, Netty IR - Santoso N FIR - Chin, Lynda IR - Chin L FIR - Park, Peter J IR - Park PJ FIR - Kucherlapati, Raju IR - Kucherlapati R FIR - Hoadley, Katherine A IR - Hoadley KA FIR - Auman, J Todd IR - Auman JT FIR - Meng, Shaowu IR - Meng S FIR - Shi, Yan IR - Shi Y FIR - Buda, Elizabeth IR - Buda E FIR - Waring, Scot IR - Waring S FIR - Veluvolu, Umadevi IR - Veluvolu U FIR - Tan, Donghui IR - Tan D FIR - Mieczkowski, Piotr A IR - Mieczkowski PA FIR - Jones, Corbin D IR - Jones CD FIR - Simons, Janae V IR - Simons JV FIR - Soloway, Matthew G IR - Soloway MG FIR - Bodenheimer, Tom IR - Bodenheimer T FIR - Jefferys, Stuart R IR - Jefferys SR FIR - Roach, Jeffrey IR - Roach J FIR - Hoyle, Alan P IR - Hoyle AP FIR - Wu, Junyuan IR - Wu J FIR - Balu, Saianand IR - Balu S FIR - Singh, Darshan IR - Singh D FIR - Prins, Jan F IR - Prins JF FIR - Marron, J S IR - Marron JS FIR - Parker, Joel S IR - Parker JS FIR - Hayes, D Neil IR - Hayes DN FIR - Perou, Charles M IR - Perou CM FIR - Liu, Jinze IR - Liu J FIR - Cope, Leslie IR - Cope L FIR - Danilova, Ludmila IR - Danilova L FIR - Weisenberger, Daniel J IR - Weisenberger DJ FIR - Maglinte, Dennis T IR - Maglinte DT FIR - Lai, Philip H IR - Lai PH FIR - Bootwalla, Moiz S IR - Bootwalla MS FIR - Van Den Berg, David J IR - Van Den Berg DJ FIR - Triche, Timothy Jr IR - Triche T Jr FIR - Baylin, Stephen B IR - Baylin SB FIR - Laird, Peter W IR - Laird PW FIR - Rosenberg, Mara IR - Rosenberg M FIR - Chin, Lynda IR - Chin L FIR - Zhang, Jianhua IR - Zhang J FIR - Cho, Juok IR - Cho J FIR - DiCara, Daniel IR - DiCara D FIR - Heiman, David IR - Heiman D FIR - Lin, Pei IR - Lin P FIR - Mallard, William IR - Mallard W FIR - Voet, Douglas IR - Voet D FIR - Zhang, Hailei IR - Zhang H FIR - Zou, Lihua IR - Zou L FIR - Noble, Michael S IR - Noble MS FIR - Lawrence, Michael S IR - Lawrence MS FIR - Saksena, Gordon IR - Saksena G FIR - Gehlenborg, Nils IR - Gehlenborg N FIR - Thorvaldsdottir, Helga IR - Thorvaldsdottir H FIR - Mesirov, Jill IR - Mesirov J FIR - Nazaire, Marc-Danie IR - Nazaire MD FIR - Robinson, Jim IR - Robinson J FIR - Getz, Gad IR - Getz G FIR - Lee, William IR - Lee W FIR - Aksoy, B Arman IR - Aksoy BA FIR - Ciriello, Giovanni IR - Ciriello G FIR - Taylor, Barry S IR - Taylor BS FIR - Dresdner, Gideon IR - Dresdner G FIR - Gao, Jianjiong IR - Gao J FIR - Gross, Benjamin IR - Gross B FIR - Seshan, Venkatraman E IR - Seshan VE FIR - Ladanyi, Marc IR - Ladanyi M FIR - Reva, Boris IR - Reva B FIR - Sinha, Rileen IR - Sinha R FIR - Sumer, S Onur IR - Sumer SO FIR - Weinhold, Nils IR - Weinhold N FIR - Schultz, Nikolaus IR - Schultz N FIR - Shen, Ronglai IR - Shen R FIR - Sander, Chris IR - Sander C FIR - Ng, Sam IR - Ng S FIR - Ma, Singer IR - Ma S FIR - Zhu, Jingchun IR - Zhu J FIR - Radenbaugh, Amie IR - Radenbaugh A FIR - Stuart, Joshua M IR - Stuart JM FIR - Benz, Christopher C IR - Benz CC FIR - Yau, Christina IR - Yau C FIR - Haussler, David IR - Haussler D FIR - Spellman, Paul T IR - Spellman PT FIR - Wilkerson, Matthew D IR - Wilkerson MD FIR - Parker, Joel S IR - Parker JS FIR - Hoadley, Katherine A IR - Hoadley KA FIR - Kimes, Patrick K IR - Kimes PK FIR - Hayes, D Neil IR - Hayes DN FIR - Perou, Charles M IR - Perou CM FIR - Broom, Bradley M IR - Broom BM FIR - Wang, Jing IR - Wang J FIR - Lu, Yiling IR - Lu Y FIR - Kwok Shing Ng, Patrick IR - Kwok Shing Ng P FIR - Diao, Lixia IR - Diao L FIR - Averett Byers, Lauren IR - Averett Byers L FIR - Liu, Wenbin IR - Liu W FIR - Heymach, John V IR - Heymach JV FIR - Amos, Christopher I IR - Amos CI FIR - Weinstein, John N IR - Weinstein JN FIR - Akbani, Rehan IR - Akbani R FIR - Mills, Gordon B IR - Mills GB FIR - Curley, Erin IR - Curley E FIR - Paulauskis, Joseph IR - Paulauskis J FIR - Lau, Kevin IR - Lau K FIR - Morris, Scott IR - Morris S FIR - Shelton, Troy IR - Shelton T FIR - Mallery, David IR - Mallery D FIR - Gardner, Johanna IR - Gardner J FIR - Penny, Robert IR - Penny R FIR - Saller, Charles IR - Saller C FIR - Tarvin, Katherine IR - Tarvin K FIR - Richards, William G IR - Richards WG FIR - Cerfolio, Robert IR - Cerfolio R FIR - Bryant, Ayesha IR - Bryant A FIR - Raymond, Daniel P IR - Raymond DP FIR - Pennell, Nathan A IR - Pennell NA FIR - Farver, Carol IR - Farver C FIR - Czerwinski, Christine IR - Czerwinski C FIR - Huelsenbeck-Dill, Lori IR - Huelsenbeck-Dill L FIR - Iacocca, Mary IR - Iacocca M FIR - Petrelli, Nicholas IR - Petrelli N FIR - Rabeno, Brenda IR - Rabeno B FIR - Brown, Jennifer IR - Brown J FIR - Bauer, Thomas IR - Bauer T FIR - Dolzhanskiy, Oleg IR - Dolzhanskiy O FIR - Potapova, Olga IR - Potapova O FIR - Rotin, Daniil IR - Rotin D FIR - Voronina, Olga IR - Voronina O FIR - Nemirovich-Danchenko, Elena IR - Nemirovich-Danchenko E FIR - Fedosenko, Konstantin V IR - Fedosenko KV FIR - Gal, Anthony IR - Gal A FIR - Behera, Madhusmita IR - Behera M FIR - Ramalingam, Suresh S IR - Ramalingam SS FIR - Sica, Gabriel IR - Sica G FIR - Flieder, Douglas IR - Flieder D FIR - Boyd, Jeff IR - Boyd J FIR - Weaver, JoEllen IR - Weaver J FIR - Kohl, Bernard IR - Kohl B FIR - Huy Quoc Thinh, Dang IR - Huy Quoc Thinh D FIR - Sandusky, George IR - Sandusky G FIR - Juhl, Hartmut IR - Juhl H FIR - Duhig, Edwina IR - Duhig E FIR - Illei, Peter IR - Illei P FIR - Gabrielson, Edward IR - Gabrielson E FIR - Shin, James IR - Shin J FIR - Lee, Beverly IR - Lee B FIR - Rodgers, Kristen IR - Rodgers K FIR - Trusty, Dante IR - Trusty D FIR - Brock, Malcolm V IR - Brock MV FIR - Williamson, Christina IR - Williamson C FIR - Burks, Eric IR - Burks E FIR - Rieger-Christ, Kimberly IR - Rieger-Christ K FIR - Holway, Antonia IR - Holway A FIR - Sullivan, Travis IR - Sullivan T FIR - Wigle, Dennis A IR - Wigle DA FIR - Asiedu, Michael K IR - Asiedu MK FIR - Kosari, Farhad IR - Kosari F FIR - Travis, William D IR - Travis WD FIR - Rekhtman, Natasha IR - Rekhtman N FIR - Zakowski, Maureen IR - Zakowski M FIR - Rusch, Valerie W IR - Rusch VW FIR - Zippile, Paul IR - Zippile P FIR - Suh, James IR - Suh J FIR - Pass, Harvey IR - Pass H FIR - Goparaju, Chandra IR - Goparaju C FIR - Owusu-Sarpong, Yvonne IR - Owusu-Sarpong Y FIR - Bartlett, John M S IR - Bartlett JM FIR - Kodeeswaran, Sugy IR - Kodeeswaran S FIR - Parfitt, Jeremy IR - Parfitt J FIR - Sekhon, Harmanjatinder IR - Sekhon H FIR - Albert, Monique IR - Albert M FIR - Eckman, John IR - Eckman J FIR - Myers, Jerome B IR - Myers JB FIR - Cheney, Richard IR - Cheney R FIR - Morrison, Carl IR - Morrison C FIR - Gaudioso, Carmelo IR - Gaudioso C FIR - Borgia, Jeffrey A IR - Borgia JA FIR - Bonomi, Philip IR - Bonomi P FIR - Pool, Mark IR - Pool M FIR - Liptay, Michael J IR - Liptay MJ FIR - Moiseenko, Fedor IR - Moiseenko F FIR - Zaytseva, Irina IR - Zaytseva I FIR - Dienemann, Hendrik IR - Dienemann H FIR - Meister, Michael IR - Meister M FIR - Schnabel, Philipp A IR - Schnabel PA FIR - Muley, Thomas R IR - Muley TR FIR - Peifer, Martin IR - Peifer M FIR - Gomez-Fernandez, Carmen IR - Gomez-Fernandez C FIR - Herbert, Lynn IR - Herbert L FIR - Egea, Sophie IR - Egea S FIR - Huang, Mei IR - Huang M FIR - Thorne, Leigh B IR - Thorne LB FIR - Boice, Lori IR - Boice L FIR - Hill Salazar, Ashley IR - Hill Salazar A FIR - Funkhouser, William K IR - Funkhouser WK FIR - Rathmell, W Kimryn IR - Rathmell WK FIR - Dhir, Rajiv IR - Dhir R FIR - Yousem, Samuel A IR - Yousem SA FIR - Dacic, Sanja IR - Dacic S FIR - Schneider, Frank IR - Schneider F FIR - Siegfried, Jill M IR - Siegfried JM FIR - Hajek, Richard IR - Hajek R FIR - Watson, Mark A IR - Watson MA FIR - McDonald, Sandra IR - McDonald S FIR - Meyers, Bryan IR - Meyers B FIR - Clarke, Belinda IR - Clarke B FIR - Yang, Ian A IR - Yang IA FIR - Fong, Kwun M IR - Fong KM FIR - Hunter, Lindy IR - Hunter L FIR - Windsor, Morgan IR - Windsor M FIR - Bowman, Rayleen V IR - Bowman RV FIR - Peters, Solange IR - Peters S FIR - Letovanec, Igor IR - Letovanec I FIR - Khan, Khurram Z IR - Khan KZ FIR - Jensen, Mark A IR - Jensen MA FIR - Snyder, Eric E IR - Snyder EE FIR - Srinivasan, Deepak IR - Srinivasan D FIR - Kahn, Ari B IR - Kahn AB FIR - Baboud, Julien IR - Baboud J FIR - Pot, David A IR - Pot DA FIR - Mills Shaw, Kenna R IR - Mills Shaw KR FIR - Sheth, Margi IR - Sheth M FIR - Davidsen, Tanja IR - Davidsen T FIR - Demchok, John A IR - Demchok JA FIR - Yang, Liming IR - Yang L FIR - Wang, Zhining IR - Wang Z FIR - Tarnuzzer, Roy IR - Tarnuzzer R FIR - Zenklusen, Jean Claude IR - Zenklusen JC FIR - Ozenberger, Bradley A IR - Ozenberger BA FIR - Sofia, Heidi J IR - Sofia HJ FIR - Travis, William D IR - Travis WD FIR - Cheney, Richard IR - Cheney R FIR - Clarke, Belinda IR - Clarke B FIR - Dacic, Sanja IR - Dacic S FIR - Duhig, Edwina IR - Duhig E FIR - Funkhouser, William K IR - Funkhouser WK FIR - Illei, Peter IR - Illei P FIR - Farver, Carol IR - Farver C FIR - Rekhtman, Natasha IR - Rekhtman N FIR - Sica, Gabriel IR - Sica G FIR - Suh, James IR - Suh J FIR - Tsao, Ming-Sound IR - Tsao MS FIR - Travis, William D IR - Travis WD FIR - Cheney, Richard IR - Cheney R FIR - Clarke, Belinda IR - Clarke B FIR - Dacic, Sanja IR - Dacic S FIR - Duhig, Edwina IR - Duhig E FIR - Funkhouser, William K IR - Funkhouser WK FIR - Illei, Peter IR - Illei P FIR - Farver, Carol IR - Farver C FIR - Rekhtman, Natasha IR - Rekhtman N FIR - Sica, Gabriel IR - Sica G FIR - Suh, James IR - Suh J FIR - Tsao, Ming-Sound IR - Tsao MS EDAT- 2014/08/01 06:00 MHDA- 2014/09/17 06:00 PMCR- 2014/11/14 CRDT- 2014/08/01 06:00 PHST- 2013/06/11 00:00 [received] PHST- 2014/04/22 00:00 [accepted] PHST- 2014/08/01 06:00 [entrez] PHST- 2014/08/01 06:00 [pubmed] PHST- 2014/09/17 06:00 [medline] PHST- 2014/11/14 00:00 [pmc-release] AID - nature13385 [pii] AID - 10.1038/nature13385 [doi] PST - ppublish SO - Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9.