PMID- 25082799
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20220330
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Print)
IS  - 1522-8517 (Linking)
VI  - 16
IP  - 12
DP  - 2014 Dec
TI  - Targeting adaptive glioblastoma: an overview of proliferation and invasion.
PG  - 1575-84
LID - 10.1093/neuonc/nou147 [doi]
AB  - Glioblastoma is one of the most devastating cancers, in which tumor cell 
      infiltration into surrounding normal brain tissue confounds clinical management. 
      This review describes basic and translational research into glioma proliferation 
      and invasion, in particular the phenotypic switch underlying a stochastic "go or 
      grow" model of tumor cell behavior. We include recent progress in system 
      genomics, cancer stem cell theory, and tumor-microenvironment interaction, from 
      which novel therapeutic strategies may emerge for managing this malignant 
      disease. We suggest that an effective therapeutic strategy should target both 
      adaptive glioblastoma cells and the stroma-tumor interaction.
CI  - (c) The Author(s) 2014. Published by Oxford University Press on behalf of the 
      Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Xie, Qian
AU  - Xie Q
AD  - Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, 
      Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, 
      Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); 
      Cancer and Cell Biology Division, Translational Genomics Research Institute, 
      Phoenix, Arizona (M.E.B.).
FAU - Mittal, Sandeep
AU  - Mittal S
AD  - Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, 
      Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, 
      Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); 
      Cancer and Cell Biology Division, Translational Genomics Research Institute, 
      Phoenix, Arizona (M.E.B.).
FAU - Berens, Michael E
AU  - Berens ME
AD  - Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, 
      Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, 
      Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); 
      Cancer and Cell Biology Division, Translational Genomics Research Institute, 
      Phoenix, Arizona (M.E.B.).
LA  - eng
GR  - R01 CA123451/CA/NCI NIH HHS/United States
GR  - U01CA168397/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140730
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
SB  - IM
MH  - Brain Neoplasms/pathology/*physiopathology/*therapy
MH  - Cell Proliferation
MH  - Glioblastoma/pathology/*physiopathology/*therapy
MH  - Humans
MH  - Neoplasm Invasiveness/physiopathology
PMC - PMC4232088
OTO - NOTNLM
OT  - glioblastoma
OT  - invasion
OT  - proliferation
OT  - targeted therapy
EDAT- 2014/08/02 06:00
MHDA- 2015/07/07 06:00
PMCR- 2015/12/01
CRDT- 2014/08/02 06:00
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - nou147 [pii]
AID - 10.1093/neuonc/nou147 [doi]
PST - ppublish
SO  - Neuro Oncol. 2014 Dec;16(12):1575-84. doi: 10.1093/neuonc/nou147. Epub 2014 Jul 
      30.