PMID- 25107277
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211203
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 3
DP  - 2014 Aug 8
TI  - The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates 
      Dachs localization and Hippo signaling.
PG  - e03383
LID - 10.7554/eLife.03383 [doi]
LID - e03383
AB  - The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity 
      (PCP) and proximodistal patterning. A key downstream component of Ft signaling is 
      the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft 
      have been implicated in regulating growth and PCP but how Ft regulates D is not 
      known. Mutations in Fbxl7, which encodes an F-box protein, result in tissue 
      overgrowth and abnormalities in proximodistal patterning that phenocopy deleting 
      a specific portion of the intracellular domain (ICD) of Ft that regulates both 
      growth and PCP. Fbxl7 binds to this same portion of the Ft ICD, co-localizes with 
      Ft to the proximal edge of cells and regulates the levels and asymmetry of D at 
      the apical membrane. Fbxl7 can also regulate the trafficking of proteins between 
      the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset 
      of pathways downstream of Ft and links Ft to D localization.
CI  - Copyright (c) 2014, Bosch et al.
FAU - Bosch, Justin A
AU  - Bosch JA
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, United States.
FAU - Sumabat, Taryn M
AU  - Sumabat TM
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, United States.
FAU - Hafezi, Yassi
AU  - Hafezi Y
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, United States.
FAU - Pellock, Brett J
AU  - Pellock BJ
AD  - Department of Biology, Providence College, Providence, United States.
FAU - Gandhi, Kevin D
AU  - Gandhi KD
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, United States.
FAU - Hariharan, Iswar K
AU  - Hariharan IK
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, United States ikh@berkeley.edu.
LA  - eng
GR  - R01 GM061672/GM/NIGMS NIH HHS/United States
GR  - T32 HL007544/HL/NHLBI NIH HHS/United States
GR  - R01GM61672/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140808
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Drosophila Proteins)
RN  - 0 (F-Box Proteins)
RN  - 0 (Fbxl7 protein, Drosophila)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (dachs protein, Drosophila)
RN  - 0 (ft protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Body Patterning/genetics
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Cell Polarity/genetics
MH  - Drosophila Proteins/genetics/*metabolism
MH  - Drosophila melanogaster/genetics/growth & development/*metabolism
MH  - F-Box Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Mutation
MH  - Myosins/genetics/*metabolism
MH  - Protein Binding
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - Protein Structure, Tertiary
MH  - Protein Transport
MH  - Signal Transduction
MH  - Transport Vesicles
PMC - PMC4144329
OTO - NOTNLM
OT  - Hippo pathway
OT  - cadherin
OT  - cell proliferation
OT  - planar cell polarity
OT  - ubiquitin
OT  - vesicle
COIS- The authors declare that no competing interests exist.
EDAT- 2014/08/12 06:00
MHDA- 2015/05/15 06:00
PMCR- 2014/08/09
CRDT- 2014/08/10 06:00
PHST- 2014/08/10 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2014/08/09 00:00 [pmc-release]
AID - 03383 [pii]
AID - 10.7554/eLife.03383 [doi]
PST - epublish
SO  - Elife. 2014 Aug 8;3:e03383. doi: 10.7554/eLife.03383.