PMID- 25183867 OWN - NLM STAT- MEDLINE DCOM- 20141028 LR - 20220331 IS - 1477-9129 (Electronic) IS - 0950-1991 (Print) IS - 0950-1991 (Linking) VI - 141 IP - 18 DP - 2014 Sep TI - Roles for Hedgehog signaling in adult organ homeostasis and repair. PG - 3445-57 LID - 10.1242/dev.083691 [doi] AB - The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions during development, and HH signaling continues in discrete populations of cells within many adult mammalian tissues. Growing evidence indicates that HH regulates diverse quiescent stem cell populations, but the exact roles that HH signaling plays in adult organ homeostasis and regeneration remain poorly understood. Here, we review recently identified functions of HH in modulating the behavior of tissue-specific adult stem and progenitor cells during homeostasis, regeneration and disease. We conclude that HH signaling is a key factor in the regulation of adult tissue homeostasis and repair, acting via multiple different routes to regulate distinct cellular outcomes, including maintenance of plasticity, in a context-dependent manner. CI - (c) 2014. Published by The Company of Biologists Ltd. FAU - Petrova, Ralitsa AU - Petrova R AD - Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA BCMB Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. FAU - Joyner, Alexandra L AU - Joyner AL AD - Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA BCMB Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA joynera@mskcc.org. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Development JT - Development (Cambridge, England) JID - 8701744 RN - 0 (Hedgehog Proteins) SB - IM MH - Adult MH - Adult Stem Cells/*physiology MH - Germ Layers/*metabolism MH - Hedgehog Proteins/*metabolism MH - Homeostasis/*physiology MH - Humans MH - *Models, Biological MH - Signal Transduction/*physiology PMC - PMC4197719 OTO - NOTNLM OT - Adult stem cells OT - Hedgehog signaling OT - Homeostasis EDAT- 2014/09/04 06:00 MHDA- 2014/10/29 06:00 PMCR- 2015/09/01 CRDT- 2014/09/04 06:00 PHST- 2014/09/04 06:00 [entrez] PHST- 2014/09/04 06:00 [pubmed] PHST- 2014/10/29 06:00 [medline] PHST- 2015/09/01 00:00 [pmc-release] AID - 141/18/3445 [pii] AID - DEV083691 [pii] AID - 10.1242/dev.083691 [doi] PST - ppublish SO - Development. 2014 Sep;141(18):3445-57. doi: 10.1242/dev.083691.