PMID- 25342631
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20240109
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 14
IP  - 11
DP  - 2014 Nov
TI  - Revisiting STAT3 signalling in cancer: new and unexpected biological functions.
PG  - 736-46
LID - 10.1038/nrc3818 [doi]
AB  - The Janus kinases (JAKs) and signal transducer and activator of transcription 
      (STAT) proteins, particularly STAT3, are among the most promising new targets for 
      cancer therapy. In addition to interleukin-6 (IL-6) and its family members, 
      multiple pathways, including G-protein-coupled receptors (GPCRs), Toll-like 
      receptors (TLRs) and microRNAs were recently identified to regulate JAK-STAT 
      signalling in cancer. Well known for its role in tumour cell proliferation, 
      survival, invasion and immunosuppression, JAK-STAT3 signalling also promotes 
      cancer through inflammation, obesity, stem cells and the pre-metastatic niche. In 
      addition to its established role as a transcription factor in cancer, STAT3 
      regulates mitochondrion functions, as well as gene expression through epigenetic 
      mechanisms. Newly identified regulators and functions of JAK-STAT3 in tumours are 
      important targets for potential therapeutic strategies in the treatment of 
      cancer.
FAU - Yu, Hua
AU  - Yu H
AD  - Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research 
      Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, 
      USA.
FAU - Lee, Heehyoung
AU  - Lee H
AD  - Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research 
      Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, 
      USA.
FAU - Herrmann, Andreas
AU  - Herrmann A
AD  - Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research 
      Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, 
      USA.
FAU - Buettner, Ralf
AU  - Buettner R
AD  - Department of Molecular Medicine, Beckman Research Institute, City of Hope 
      Comprehensive Cancer Center, Duarte, California 91010, USA.
FAU - Jove, Richard
AU  - Jove R
AD  - Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida 34987, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Antineoplastic Agents)
RN  - 0 (STAT3 Transcription Factor)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/therapeutic use
MH  - Epigenesis, Genetic
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Neoplasms/drug therapy/genetics/*metabolism
MH  - STAT3 Transcription Factor/antagonists & inhibitors/genetics/*metabolism
MH  - *Signal Transduction/drug effects
EDAT- 2014/10/25 06:00
MHDA- 2014/12/23 06:00
CRDT- 2014/10/25 06:00
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - nrc3818 [pii]
AID - 10.1038/nrc3818 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2014 Nov;14(11):736-46. doi: 10.1038/nrc3818.