PMID- 2543070
OWN - NLM
STAT- MEDLINE
DCOM- 19890706
LR  - 20220317
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 244
IP  - 4907
DP  - 1989 May 26
TI  - Oxygen radicals in influenza-induced pathogenesis and treatment with pyran 
      polymer-conjugated SOD.
PG  - 974-6
AB  - The pathogenicity of influenza virus infection in the mice involves, at least in 
      part, overreaction of the immune responses of the host rather than a direct 
      effect of virus multiplication. Xanthine oxidase, which is responsible for the 
      generation of oxygen free radicals, was elevated in serum and lung tissue of mice 
      infected with influenza virus. To test the theory that oxygen-free radicals are 
      involved in pathogenesis, free radicals were removed by injecting superoxide 
      dismutase (SOD), a specific superoxide radical scavenger, which was conjugated 
      with a pyran copolymer. The conjugate protected mice against a potentially lethal 
      influenza virus infection if administered 5 to 8 days after infection. These 
      findings indicate that oxygen radicals are important in the pathogenesis of 
      influenza virus infection, and that a polymer-conjugated SOD has therapeutic 
      potential for this virus infection and other diseases associated with free 
      radicals.
FAU - Oda, T
AU  - Oda T
AD  - Department of Microbiology, Kumamoto University Medical School, Japan.
FAU - Akaike, T
AU  - Akaike T
FAU - Hamamoto, T
AU  - Hamamoto T
FAU - Suzuki, F
AU  - Suzuki F
FAU - Hirano, T
AU  - Hirano T
FAU - Maeda, H
AU  - Maeda H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Free Radicals)
RN  - 0 (Polymers)
RN  - 11062-77-4 (Superoxides)
RN  - 27100-68-1 (Pyran Copolymer)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid
MH  - Free Radicals
MH  - Lung/enzymology/pathology
MH  - Mice
MH  - Orthomyxoviridae Infections/drug therapy/*metabolism/pathology
MH  - Oxygen/*metabolism
MH  - Phagocytes/metabolism/pathology
MH  - *Polymers/administration & dosage/therapeutic use
MH  - *Pyran Copolymer/administration & dosage/therapeutic use
MH  - Superoxide Dismutase/administration & dosage/pharmacokinetics/*therapeutic use
MH  - Superoxides/metabolism
MH  - Xanthine Oxidase/blood/metabolism
EDAT- 1989/05/26 00:00
MHDA- 1989/05/26 00:01
CRDT- 1989/05/26 00:00
PHST- 1989/05/26 00:00 [pubmed]
PHST- 1989/05/26 00:01 [medline]
PHST- 1989/05/26 00:00 [entrez]
AID - 10.1126/science.2543070 [doi]
PST - ppublish
SO  - Science. 1989 May 26;244(4907):974-6. doi: 10.1126/science.2543070.