PMID- 2547508
OWN - NLM
STAT- MEDLINE
DCOM- 19890915
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 64
IP  - 5
DP  - 1989 Sep 1
TI  - Radical pancreatectomy for ductal cell carcinoma of the head of the pancreas.
PG  - 1132-7
AB  - Seventy-four patients were treated with a radical or a nonradical pancreatectomy 
      for ductal cell carcinoma of the head of the pancreas. Their survival rates and 
      the selection of the operative procedure were evaluated. In 32 patients, a 
      radical pancreatectomy was attempted where there was sufficient clearance of 
      regional or juxta-regional lymph nodes beyond the group of suspected metastatic 
      nodes, as well as a resection of a greater margin of soft tissue around the 
      pancreas. These patients' cumulative 5-year survival rate was 33.4%. In 14 Stage 
      I or Stage II patients, the cumulative 5-year survival rate was 46.4%. In 18 
      Stage III or Stage IV patients, the cumulative 5-year survival rate was 20.7%. 
      For 42 patients treated with a nonradical pancreatectomy with the dissection of 
      lymph nodes adjacent to the pancreas or of regional lymph nodes but with 
      insufficient clearance of the soft tissue around the pancreas, the cumulative 
      2-year and 3-year survival rates were 5.4% and 0%, respectively. In seven 
      patients with Stage II carcinoma, the survival rate was 16.7% after 2 years and 
      0% after three years. In 35 Stage III or Stage IV patients, the survival rate was 
      3.2% after 2 years and 0% after 3 years. Thus, the survival rates were 
      significantly higher in patients treated with radical operation than in patients 
      who had nonradical operation. These results indicate that a radical 
      pancreatectomy with sufficient lymph node clearance with the surrounding 
      connective tissue around the pancreas is indispensable to cure patients with 
      ductal cell carcinoma of the pancreas.
FAU - Manabe, T
AU  - Manabe T
AD  - First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
FAU - Ohshio, G
AU  - Ohshio G
FAU - Baba, N
AU  - Baba N
FAU - Miyashita, T
AU  - Miyashita T
FAU - Asano, N
AU  - Asano N
FAU - Tamura, K
AU  - Tamura K
FAU - Yamaki, K
AU  - Yamaki K
FAU - Nonaka, A
AU  - Nonaka A
FAU - Tobe, T
AU  - Tobe T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Intraductal, Noninfiltrating/pathology/*surgery
MH  - Duodenum/surgery
MH  - Female
MH  - Humans
MH  - Lymph Nodes/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/pathology/*surgery
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1002/1097-0142(19890901)64:5<1132::aid-cncr2820640528>3.0.co;2-v [doi]
PST - ppublish
SO  - Cancer. 1989 Sep 1;64(5):1132-7. doi: 
      10.1002/1097-0142(19890901)64:5<1132::aid-cncr2820640528>3.0.co;2-v.