PMID- 2553231
OWN - NLM
STAT- MEDLINE
DCOM- 19891220
LR  - 20190828
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 16
IP  - 4 Suppl
DP  - 1989 Nov
TI  - Ultrastructural studies of the cells forming amyloid fibers in classical plaques.
PG  - 535-42
AB  - Three-dimensional reconstruction and ultrastructural studies of classical plaques 
      from the cortex of patients with Alzheimer's disease showed that microglial cells 
      of the plaques are the amyloid-forming cells. The amyloid star of the single 
      plaque represents the product of five or six microglial cells covering about 80% 
      of the amyloid star surface. The amyloid fibers appear to be formed within 
      altered cisterns of the endoplasmic reticulum. Distended cisterns form channels 
      filled with amyloid fibers. Numerous vesicles derived from the Golgi apparatus 
      appear to be attached to or fused with the amyloid-filled channels. 
      Reconstruction of the amyloid star and the microglia cell pole that forms the 
      amyloid star reveals three different zones of distribution of cytoplasmic 
      organelles and amyloid deposits. The peripheral zone comprises channels filled 
      with loosely packed amyloid fibers arranged in a parallel manner. The transient 
      zone consists of a mixture of fusing amyloid channels and products of 
      disintegration of cytoplasmic pockets, dense bodies and fragments of cellular 
      membranes. The core of the amyloid star is composed of condensed, densely packed 
      amyloid fibers that are free of cellular debris. Formation of the three zones 
      supports the idea that the microglia/macrophages are not phagocytes but instead 
      are the cells manufacturing the amyloid fibers.
FAU - Wisniewski, H M
AU  - Wisniewski HM
AD  - Department of Pathological Neurobiology, New York State Institute for Basic 
      Research in Development Disabilities, Staten Island 10314.
FAU - Wegiel, J
AU  - Wegiel J
FAU - Wang, K C
AU  - Wang KC
FAU - Kujawa, M
AU  - Kujawa M
FAU - Lach, B
AU  - Lach B
LA  - eng
GR  - FO TWO 3849/TW/FIC NIH HHS/United States
GR  - P0-1-AGO-4220-05/AG/NIA NIH HHS/United States
GR  - P0-1-HD-22634-03/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - 0 (Amyloid)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*pathology
MH  - Amyloid/*metabolism
MH  - Endoplasmic Reticulum/metabolism/ultrastructure
MH  - Female
MH  - Golgi Apparatus/metabolism/ultrastructure
MH  - Humans
MH  - Inclusion Bodies/*ultrastructure
MH  - Microscopy, Electron
MH  - Neuroglia/*metabolism/ultrastructure
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1017/s0317167100029887 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 1989 Nov;16(4 Suppl):535-42. doi: 10.1017/s0317167100029887.