PMID- 25984556
OWN - NLM
STAT- PubMed-not-MEDLINE
LR - 20230928
IS - 2352-4820 (Print)
IS - 2352-3042 (Electronic)
IS - 2352-3042 (Linking)
VI - 2
IP - 1
DP - 2015 Mar 1
TI - Insulin-like growth factor (IGF) signaling in tumorigenesis and the development
of cancer drug resistance.
PG - 13-25
AB - One of the greatest obstacles to current cancer treatment efforts is the
development of drug resistance by tumors. Despite recent advances in diagnostic
practices and surgical interventions, many neoplasms demonstrate poor response to
adjuvant or neoadjuvant radiation and chemotherapy. As a result, the prognosis
for many patients afflicted with these aggressive cancers remains bleak. The
insulin-like growth factor (IGF) signaling axis has been shown to play critical
role in the development and progression of various tumors. Many basic science and
translational studies have shown that IGF pathway modulators can have promising
effects when used to treat various malignancies. There also exists a substantial
body of recent evidence implicating IGF signaling dysregulation in the dwindling
response of tumors to current standard-of-care therapy. By better understanding
both the IGF-dependent and -independent mechanisms by which pathway members can
influence drug sensitivity, we can eventually aim to use modulators of IGF
signaling to augment the effects of current therapy. This review summarizes and
synthesizes numerous recent investigations looking at the role of the IGF pathway
in drug resistance. We offer a brief overview of IGF signaling and its general
role in neoplasia, and then delve into detail about the many types of human
cancer that have been shown to have IGF pathway involvement in resistance and/or
sensitization to therapy. Ultimately, our hope is that such a compilation of
evidence will compel investigators to carry out much needed studies looking at
combination treatment with IGF signaling modulators to overcome current therapy
resistance.
FAU - Denduluri, Sahitya K
AU - Denduluri SK
AD - The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA ;
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA.
FAU - Idowu, Olumuyiwa
AU - Idowu O
AD - The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA ;
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA.
FAU - Wang, Zhongliang
AU - Wang Z
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Ministry of Education Key Laboratory of Diagnostic Medicine, The Affiliated
Hospitals of Chongqing Medical University, Chongqing 400016, China.
FAU - Liao, Zhan
AU - Liao Z
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Department of Orthopaedic Surgery, Xiang-Ya Hospital of Central South
University, Changsha 410008, China.
FAU - Yan, Zhengjian
AU - Yan Z
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Ministry of Education Key Laboratory of Diagnostic Medicine, The Affiliated
Hospitals of Chongqing Medical University, Chongqing 400016, China.
FAU - Mohammed, Maryam K
AU - Mohammed MK
AD - The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA ;
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA.
FAU - Ye, Jixing
AU - Ye J
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; School of Bioengineering, Chongqing University, Chongqing, China.
FAU - Wei, Qiang
AU - Wei Q
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Ministry of Education Key Laboratory of Diagnostic Medicine, The Affiliated
Hospitals of Chongqing Medical University, Chongqing 400016, China.
FAU - Wang, Jing
AU - Wang J
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Ministry of Education Key Laboratory of Diagnostic Medicine, The Affiliated
Hospitals of Chongqing Medical University, Chongqing 400016, China.
FAU - Zhao, Lianggong
AU - Zhao L
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA ; Department of Orthopaedic Surgery, the Second Affiliated Hospital of
Lanzhou University, Lanzhou, Gansu 730000, China.
FAU - Luu, Hue H
AU - Luu HH
AD - Molecular Oncology Laboratory, Department of Orthopaedic Surgery and
Rehabilitation Medicine, 5841 South Maryland Avenue, MC 3079, Chicago, IL 60637,
USA.
LA - eng
GR - K08 AR054381/AR/NIAMS NIH HHS/United States
GR - UL1 TR000430/TR/NCATS NIH HHS/United States
PT - Journal Article
PL - Netherlands
TA - Genes Dis
JT - Genes & diseases
JID - 101635967
PMC - PMC4431759
MID - NIHMS646154
OTO - NOTNLM
OT - Cancer
OT - Insulin-like growth factor
OT - Resistance
OT - Therapy
OT - Tumorigenesis
EDAT- 2015/05/20 06:00
MHDA- 2015/05/20 06:01
PMCR- 2014/11/15
CRDT- 2015/05/19 06:00
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2015/05/20 06:01 [medline]
PHST- 2014/11/15 00:00 [pmc-release]
AID - S2352-3042(14)00037-3 [pii]
AID - 10.1016/j.gendis.2014.10.004 [doi]
PST - ppublish
SO - Genes Dis. 2015 Mar 1;2(1):13-25. doi: 10.1016/j.gendis.2014.10.004.