PMID- 26058969
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20190108
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Jun 10
TI  - Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based 
      Approach.
PG  - 10649
LID - 10.1038/srep10649 [doi]
LID - 10649
AB  - Blood-mediated nanoparticle delivery is a new and growing field in the 
      development of therapeutics and diagnostics. Nanoparticle properties such as 
      size, shape and surface chemistry can be controlled to improve their performance 
      in biological systems. This enables modulation of immune system interactions, 
      blood clearance profile and interaction with target cells, thereby aiding 
      effective delivery of cargo within cells or tissues. Their ability to target and 
      enter tissues from the blood is highly dependent on their behaviour under blood 
      flow. Here we have produced an agent-based model of nanoparticle behaviour under 
      blood flow in capillaries. We demonstrate that red blood cells are highly 
      important for effective nanoparticle distribution within capillaries. 
      Furthermore, we use this model to demonstrate how nanoparticle size can 
      selectively target tumour tissue over normal tissue. We demonstrate that the 
      polydispersity of nanoparticle populations is an important consideration in 
      achieving optimal specificity and to avoid off-target effects. In future this 
      model could be used for informing new nanoparticle design and to predict general 
      and specific uptake properties under blood flow.
FAU - Fullstone, Gavin
AU  - Fullstone G
AD  - 1] Department of Chemistry, University College London, UK [2] MRC Centre for 
      Molecular Virology, University College London, UK [3] Department of Computer 
      Science, University of Sheffield, UK.
FAU - Wood, Jonathan
AU  - Wood J
AD  - Sheffield Institute for Translational Neuroscience, University of Sheffield, UK.
FAU - Holcombe, Mike
AU  - Holcombe M
AD  - Department of Computer Science, University of Sheffield, UK.
FAU - Battaglia, Giuseppe
AU  - Battaglia G
AD  - 1] Department of Chemistry, University College London, UK [2] MRC Centre for 
      Molecular Virology, University College London, UK.
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150610
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Biological Transport
MH  - *Blood Circulation
MH  - Erythrocytes/metabolism
MH  - Humans
MH  - *Nanoparticles
PMC - PMC4462051
EDAT- 2015/06/11 06:00
MHDA- 2016/03/29 06:00
PMCR- 2015/06/10
CRDT- 2015/06/11 06:00
PHST- 2014/12/18 00:00 [received]
PHST- 2015/03/16 00:00 [accepted]
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
PHST- 2015/06/10 00:00 [pmc-release]
AID - srep10649 [pii]
AID - 10.1038/srep10649 [doi]
PST - epublish
SO  - Sci Rep. 2015 Jun 10;5:10649. doi: 10.1038/srep10649.