PMID- 26120961 OWN - NLM STAT- MEDLINE DCOM- 20151021 LR - 20231111 IS - 1546-1726 (Electronic) IS - 1097-6256 (Print) IS - 1097-6256 (Linking) VI - 18 IP - 8 DP - 2015 Aug TI - Different immune cells mediate mechanical pain hypersensitivity in male and female mice. PG - 1081-3 LID - 10.1038/nn.4053 [doi] AB - A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research. FAU - Sorge, Robert E AU - Sorge RE AD - 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Mapplebeck, Josiane C S AU - Mapplebeck JC AD - 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [3] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [4] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada. FAU - Rosen, Sarah AU - Rosen S AD - Department of Psychology, McGill University, Montreal, Quebec, Canada. FAU - Beggs, Simon AU - Beggs S AD - 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada. FAU - Taves, Sarah AU - Taves S AD - Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA. FAU - Alexander, Jessica K AU - Alexander JK AD - 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada. FAU - Martin, Loren J AU - Martin LJ AD - Department of Psychology, McGill University, Montreal, Quebec, Canada. FAU - Austin, Jean-Sebastien AU - Austin JS AD - Department of Psychology, McGill University, Montreal, Quebec, Canada. FAU - Sotocinal, Susana G AU - Sotocinal SG AD - Department of Psychology, McGill University, Montreal, Quebec, Canada. FAU - Chen, Di AU - Chen D AD - Department of Psychology, McGill University, Montreal, Quebec, Canada. FAU - Yang, Mu AU - Yang M AD - Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. FAU - Shi, Xiang Qun AU - Shi XQ AD - Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. FAU - Huang, Hao AU - Huang H AD - Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. FAU - Pillon, Nicolas J AU - Pillon NJ AD - Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Bilan, Philip J AU - Bilan PJ AD - Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Tu, YuShan AU - Tu Y AD - Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Klip, Amira AU - Klip A AD - Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Ji, Ru-Rong AU - Ji RR AD - Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA. FAU - Zhang, Ji AU - Zhang J AD - 1] Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. [2] Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada. FAU - Salter, Michael W AU - Salter MW AUID- ORCID: 0000000168976585 AD - 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada. FAU - Mogil, Jeffrey S AU - Mogil JS AD - 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada. LA - eng GR - R01 DE017794/DE/NIDCR NIH HHS/United States GR - MOP-123307/Canadian Institutes of Health Research/Canada GR - R01-DE17794/DE/NIDCR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150629 PL - United States TA - Nat Neurosci JT - Nature neuroscience JID - 9809671 SB - IM CIN - Nat Rev Immunol. 2015 Aug;15(8):469. PMID: 26184714 CIN - Nat Neurosci. 2015 Aug;18(8):1059-60. PMID: 26216458 MH - Animals MH - Disease Models, Animal MH - Female MH - Hyperalgesia/*immunology MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Mice, Transgenic MH - Microglia/*metabolism MH - Neuralgia/*immunology MH - *Sex Characteristics MH - Sex Factors MH - Signal Transduction/*physiology MH - T-Lymphocytes/*metabolism PMC - PMC4772157 MID - NIHMS762591 COIS- COMPETING FINANCIAL INTERESTS STATEMENT The authors have no competing interests as defined by Nature Publishing Group, or other interests that might be perceived to influence the results and/or discussion reported in this article. EDAT- 2015/06/30 06:00 MHDA- 2015/10/22 06:00 PMCR- 2016/03/01 CRDT- 2015/06/30 06:00 PHST- 2015/04/10 00:00 [received] PHST- 2015/06/02 00:00 [accepted] PHST- 2015/06/30 06:00 [entrez] PHST- 2015/06/30 06:00 [pubmed] PHST- 2015/10/22 06:00 [medline] PHST- 2016/03/01 00:00 [pmc-release] AID - nn.4053 [pii] AID - 10.1038/nn.4053 [doi] PST - ppublish SO - Nat Neurosci. 2015 Aug;18(8):1081-3. doi: 10.1038/nn.4053. Epub 2015 Jun 29.