PMID- 26137500
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 2352-4820 (Print)
IS  - 2352-3042 (Electronic)
IS  - 2352-3042 (Linking)
VI  - 2
IP  - 2
DP  - 2015 Jun
TI  - Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between 
      differentiated non-GSCs and GSCs.
PG  - 152-163
AB  - Cancer stem cells (CSCs) or cancer initiating cells (CICs) maintain self-renewal 
      and multilineage differentiation properties of various tumors, as well as the 
      cellular heterogeneity consisting of several subpopulations within tumors. CSCs 
      display the malignant phenotype, self-renewal ability, altered genomic stability, 
      specific epigenetic signature, and most of the time can be phenotyped by cell 
      surface markers (e.g., CD133, CD24, and CD44). Numerous studies support the 
      concept that non-stem cancer cells (non-CSCs) are sensitive to cancer therapy 
      while CSCs are relatively resistant to treatment. In glioblastoma stem cells 
      (GSCs), there is clonal heterogeneity at the genetic level with distinct 
      tumorigenic potential, and defined GSC marker expression resulting from clonal 
      evolution which is likely to influence disease progression and response to 
      treatment. Another level of complexity in glioblastoma multiforme (GBM) tumors is 
      the dynamic equilibrium between GSCs and differentiated non-GSCs, and the 
      potential for non-GSCs to revert (dedifferentiate) to GSCs due to epigenetic 
      alteration which confers phenotypic plasticity to the tumor cell population. 
      Moreover, exposure of the differentiated GBM cells to therapeutic doses of 
      temozolomide (TMZ) or ionizing radiation (IR) increases the GSC pool both in 
      vitro and in vivo. This review describes various subtypes of GBM, discusses the 
      evolution of CSC models and epigenetic plasticity, as well as interconversion 
      between GSCs and differentiated non-GSCs, and offers strategies to potentially 
      eliminate GSCs.
FAU - Safa, Ahmad R
AU  - Safa AR
AD  - Indiana University Simon Cancer Center, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA ; Department of Pharmacology and Toxicology, Indiana 
      University School of Medicine, Indianapolis, IN 46202, USA.
FAU - Saadatzadeh, Mohammad Reza
AU  - Saadatzadeh MR
AD  - Indiana University Simon Cancer Center, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA ; Department of Neurosurgery, IU School of Medicine 
      and Goodman Campbell Brain and Spine, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA.
FAU - Cohen-Gadol, Aaron A
AU  - Cohen-Gadol AA
AD  - Department of Neurosurgery, IU School of Medicine and Goodman Campbell Brain and 
      Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
FAU - Pollok, Karen E
AU  - Pollok KE
AD  - Indiana University Simon Cancer Center, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA ; Department of Pharmacology and Toxicology, Indiana 
      University School of Medicine, Indianapolis, IN 46202, USA ; Herman B. Wells 
      Center for Pediatric Research, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA.
FAU - Bijangi-Vishehsaraei, Khadijeh
AU  - Bijangi-Vishehsaraei K
AD  - Department of Pharmacology and Toxicology, Indiana University School of Medicine, 
      Indianapolis, IN 46202, USA ; Otolaryngology-Head and Neck Surgery, Indiana 
      University School of Medicine, Indianapolis, IN 46202, USA.
LA  - eng
GR  - R01 CA138798/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Genes Dis
JT  - Genes & diseases
JID - 101635967
PMC - PMC4484766
MID - NIHMS692315
OTO - NOTNLM
OT  - Cancer stem cells
OT  - Dedifferentiation
OT  - Epigenetic
OT  - GBM plasticity
OT  - GBM stem cells
OT  - Glioblastoma
OT  - Stemness
EDAT- 2015/07/03 06:00
MHDA- 2015/07/03 06:01
PMCR- 2015/02/14
CRDT- 2015/07/03 06:00
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2015/07/03 06:01 [medline]
PHST- 2015/02/14 00:00 [pmc-release]
AID - S2352-3042(15)00009-4 [pii]
AID - 10.1016/j.gendis.2015.02.001 [doi]
PST - ppublish
SO  - Genes Dis. 2015 Jun;2(2):152-163. doi: 10.1016/j.gendis.2015.02.001.