PMID- 26217226
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150728
LR  - 20200930
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 6
DP  - 2015
TI  - Sonochemotherapy: from bench to bedside.
PG  - 138
LID - 10.3389/fphar.2015.00138 [doi]
LID - 138
AB  - The combination of microbubbles and ultrasound has emerged as a promising method 
      for local drug delivery. Microbubbles can be locally activated by a targeted 
      ultrasound beam, which can result in several bio-effects. For drug delivery, 
      microbubble-assisted ultrasound is used to increase vascular- and plasma membrane 
      permeability for facilitating drug extravasation and the cellular uptake of drugs 
      in the treated region, respectively. In the case of drug-loaded microbubbles, 
      these two mechanisms can be combined with local release of the drug following 
      destruction of the microbubble. The use of microbubble-assisted ultrasound to 
      deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this 
      review, the basic principles of sonochemotherapy are discussed, including aspects 
      such as the type of (drug-loaded) microbubbles used, the routes of administration 
      used in vivo, ultrasound devices and parameters, treatment schedules and safety 
      issues. Finally, the clinical translation of sonochemotherapy is discussed, 
      including the first clinical study using sonochemotherapy.
FAU - Lammertink, Bart H A
AU  - Lammertink BH
AD  - Image Guided Therapy, Imaging Division, University Medical Center Utrecht 
      Utrecht, Netherlands.
FAU - Bos, Clemens
AU  - Bos C
AD  - Image Guided Therapy, Imaging Division, University Medical Center Utrecht 
      Utrecht, Netherlands.
FAU - Deckers, Roel
AU  - Deckers R
AD  - Image Guided Therapy, Imaging Division, University Medical Center Utrecht 
      Utrecht, Netherlands.
FAU - Storm, Gert
AU  - Storm G
AD  - Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University 
      Utrecht, Netherlands ; Targeted Therapeutics, MIRA Institute for Biomedical 
      Technology and Technical Medicine, University of Twente Enschede, Netherlands.
FAU - Moonen, Chrit T W
AU  - Moonen CT
AD  - Image Guided Therapy, Imaging Division, University Medical Center Utrecht 
      Utrecht, Netherlands.
FAU - Escoffre, Jean-Michel
AU  - Escoffre JM
AD  - Image Guided Therapy, Imaging Division, University Medical Center Utrecht 
      Utrecht, Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150710
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC4498442
OTO - NOTNLM
OT  - chemotherapeutic drug
OT  - drug delivery
OT  - microbubble
OT  - sonochemotherapy
OT  - sonoporation
OT  - ultrasound
EDAT- 2015/07/29 06:00
MHDA- 2015/07/29 06:01
PMCR- 2015/07/10
CRDT- 2015/07/29 06:00
PHST- 2015/05/01 00:00 [received]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/07/29 06:01 [medline]
PHST- 2015/07/10 00:00 [pmc-release]
AID - 10.3389/fphar.2015.00138 [doi]
PST - epublish
SO  - Front Pharmacol. 2015 Jul 10;6:138. doi: 10.3389/fphar.2015.00138. eCollection 
      2015.