PMID- 26217588
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150728
LR  - 20220409
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 5
DP  - 2015
TI  - Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites.
PG  - 153
LID - 10.3389/fonc.2015.00153 [doi]
LID - 153
AB  - The central nervous system (CNS) possesses powerful local and global 
      immunosuppressive capabilities that modulate unwanted inflammatory reactions in 
      nervous tissue. These same immune-modulatory mechanisms are also co-opted by 
      malignant brain tumors and pose a formidable challenge to brain tumor 
      immunotherapy. Routes by which malignant gliomas coordinate immunosuppression 
      include the mechanical and functional barriers of the CNS; immunosuppressive 
      cytokines and catabolites; immune checkpoint molecules; tumor-infiltrating immune 
      cells; and suppressor immune cells. The challenges to overcoming tumor-induced 
      immunosuppression, however, are not unique to the brain, and several analogous 
      immunosuppressive mechanisms also exist for primary tumors outside of the CNS. 
      Ultimately, the immune responses in the CNS are linked and complementary to 
      immune processes in the periphery, and advances in tumor immunotherapy in 
      peripheral sites may therefore illuminate novel approaches to brain tumor 
      immunotherapy, and vice versa.
FAU - Perng, Powell
AU  - Perng P
AD  - Department of Neurosurgery, School of Medicine, Johns Hopkins University , 
      Baltimore, MD , USA.
FAU - Lim, Michael
AU  - Lim M
AD  - Department of Neurosurgery, School of Medicine, Johns Hopkins University , 
      Baltimore, MD , USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150706
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC4492080
OTO - NOTNLM
OT  - cancer immunosuppression
OT  - cancer immunotherapy
OT  - glioblastoma
OT  - glioma
OT  - immune privilege
OT  - tumor immunotherapy
EDAT- 2015/07/29 06:00
MHDA- 2015/07/29 06:01
PMCR- 2015/01/01
CRDT- 2015/07/29 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/07/29 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2015.00153 [doi]
PST - epublish
SO  - Front Oncol. 2015 Jul 6;5:153. doi: 10.3389/fonc.2015.00153. eCollection 2015.