PMID- 26429069
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20220408
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 22
IP  - 35
DP  - 2015
TI  - Targeting the Hippo Pathway for Anti-cancer Therapies.
PG  - 4104-17
AB  - The Hippo signaling pathway is critical in regulating tissue homeostasis, organ 
      size, and tumorigenesis. YAP and TAZ, two major effectors of the Hippo pathway, 
      function as transcriptional co-activators and promote target gene expression 
      mainly through interaction with TEAD family transcription factors. As 
      oncoproteins, YAP and TAZ are frequently activated or highly expressed in various 
      cancer specimens. Moreover, their activity has been linked to resistance to a few 
      widely used anti-cancer drugs, and YAP activation contributes to cancer relapse. 
      Thus, the Hippo pathway, especially YAP/TAZ-TEAD interaction, represents an 
      attractive target for anti-cancer therapies. Here, we will discuss potential 
      approaches to inhibit YAP/TAZ activity, and also review currently available small 
      molecules targeting the Hippo pathway.
FAU - Gong, Rui
AU  - Gong R
FAU - Yu, Fa-Xing
AU  - Yu FX
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Shanghai 200032, China. fxyu@fudan.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Small Molecule Libraries)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Hippo Signaling Pathway
MH  - Humans
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Protein Serine-Threonine Kinases/*antagonists & inhibitors/metabolism
MH  - Signal Transduction/*drug effects
MH  - Small Molecule Libraries/*pharmacology
MH  - Structure-Activity Relationship
EDAT- 2015/10/03 06:00
MHDA- 2016/06/30 06:00
CRDT- 2015/10/03 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2015/09/28 00:00 [revised]
PHST- 2015/09/29 00:00 [accepted]
PHST- 2015/10/03 06:00 [entrez]
PHST- 2015/10/03 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
AID - CMC-EPUB-70833 [pii]
AID - 10.2174/0929867322666151002112256 [doi]
PST - ppublish
SO  - Curr Med Chem. 2015;22(35):4104-17. doi: 10.2174/0929867322666151002112256.